期刊文献+

不同混合方法对抗生素骨水泥力学性能的影响 被引量:3

Influence of different mixture methods on mechanical property of antibiotic-loaded bone cement
下载PDF
导出
摘要 目的:观察不同混合方法制成的抗生素骨水泥中抗生素对骨水泥力学性能的影响,以期为临床骨水泥的使用提供实验依据。方法:将不同剂量的万古霉素按不同时相分别与40g骨水泥混合,测定各组万古霉素骨水泥的压缩强度、弯曲模量和弯曲强度。结果:2g以下万古霉素两种混合方式的力学结果均高于ISO5833标准,当骨水泥中加入3g万古霉素的时候两种混合方式与其它各组之间统计学有差异。结论:2g以下万古霉素均不影响骨水泥的力学性能,抗生素的剂量大于2g时将对骨水泥的力学性能产生影响,两种混合方法对骨水泥力学性能的无明显影响。 Objective:To observe the influence of different mixture methods on mechanical property of antibiotic-loaded bone cement in order to provide clinical experimental basis for clinical application. Methods: Different dose vancomycin were add in 40g of bone cement at different time in which compression strength,flexural modulus,flexural strength of bone cement in vitro were measured in different group. Results: The mechanical properties of antibiotic-loaded bone cement in below 2g vaneomyein group was better than international standard ISO5833, and there was significant difference among other groups when added 3g vaneomycin. Conclusion: Bone cement does not affect mechanical property of antibiotic-loaded bone cement when added 1-2g vancomycin,and can affect mechanical property of antibiotic-loaded bone cement by adding 1 -2g vaneomyein by adding above 2g antibiotics in which two mixture methods does not affect the mechanical strength of bone cement.
出处 《甘肃医药》 2013年第10期728-730,共3页 Gansu Medical Journal
关键词 抗生素 骨水泥 人工关节 感染 antibiotic bone cement artificialjoint infection
  • 相关文献

参考文献11

  • 1Haaker R,Senge A,Kramer J,et al.Osteomyelitis after endoprostheses[J].Orthopade,2004,33:431-438.
  • 2Anagnostakos KJ,Kelm T,Regitz In vitro evaluation of antibiotic release from and bacteria growth inhibition by an-tibiotic-loaded acrylic bone cement spacers[J].J Biomed Mater Res,2005,72:373-378.
  • 3Hsieh PH,CH Shih,YH Chang.Two-stage revision hip arthroplasty for infection:comparison between the interim use of antibioticloaded cement beads and a spacer prosthesis[J].J Bone Joint Surg,2004,86-A:1989-1997.
  • 4Buchholz HW,Elson RA,Heinert K.Antibiotic-loaded acrylic cement:current concepts[J].Clin Orthop,1984,190,96-108.
  • 5Espehaug B,Engesaeter LB,Vollset SE,et al.Review of 10905 primary cemented total hip replacements reported to the Norwegian arthroplasty register[J].J Bone Joint Surg,1997,79-B:590-595.
  • 6Konstantinos Anagnostakos,Philippe Wilmes,Eduard Schmitt,et al.Elution of gentamicin and vancomycin from polymethylmeth-acrylate beads and hip spacers in vivo[J].Acta Orthopaedica,2009,80 (2):193-197.
  • 7Patrick BN,Rivey MP,Allington DR.Acute renal failure associated with vancomycin-and tobramycin-laden cement in total hip arthroplasty[J].Ann Pharmacother,2006,40 (11):2037-2042.
  • 8Lautenschlager E,Jacobs J,Marshall G,et al.Mechanical properties of bone cements containing large doses of antibiotic powders[J]J Biomed Mater Res,1976,10 (6):929-938.
  • 9王毅,夏元升,韩鹏飞,陈慧妍,李杰峰,刘伟东.骨水泥振动器对提高骨水泥-骨界面结合强度的疲劳实验研究[J].中国矫形外科杂志,2008,16(16):1259-1261. 被引量:5
  • 10Danille Neut1,Otto SKluin1,Jonathan Thompson,et al.Gentamicin release from commercially-available gentamicin-loaded PMMA bone cements in a prosthesis-related interfacial gap model and their antibacterial efficacy[J].BMC Musculoskeletal Disorders,2010,11:258.

二级参考文献18

  • 1赵德伟,徐达传,崔旭.股骨头不同区域囊变对力学承载的影响[J].中华骨科杂志,2005,25(4):232-235. 被引量:35
  • 2孙嗣国,范清宇,周勇,马保安.骨水泥颗粒促进肿瘤坏死因子α诱导的破骨细胞形成及其骨吸收作用[J].中国矫形外科杂志,2005,13(13):1003-1006. 被引量:6
  • 3李永奖,张力成,杨国敬,汤呈宣,郑进佑.全髋关节置换术生物力学有限元分析的研究进展[J].中华创伤骨科杂志,2007,9(3):277-280. 被引量:14
  • 4吴荣寰,林向进.髋关节置换后假体无菌性松动机制研究[J].国际骨科学杂志,2007,28(2):122-124. 被引量:5
  • 5Buchholz HW, Engelbrecht H. Uber die Depotwirkung einiger Antibiotica ber Vermischung mit dem Kunstharz Palacos. Chirurg,1970, 41: 511-515.
  • 6Hoff SF, Fitzgerald RH Jr, Kelly PJ. The depot administration of penicillin G and gentamicin in acrylic bone cement. J Bone Joint Surg (Am), 1981, 63: 798-804.
  • 7Lodenkamper H, Lodenkamper U, Trompa K. Uber die ausscheidung von antibiotika aus dem knochezement palacos [Eigene erfahrungen aus bakteriologischer sict nach 10 jahriger anwedung in der gelenckersatzchirurgie]. Z Orthop Ihre Grenzgeb, 1982, 120:801-805.
  • 8Brien WW, Salvati EA, Klein R, et al. Antibiotic impregnated bone cement in total hip arthoplasty. An in vivo comparison of the elution properties of tobramycin and vancomycin. Clin Orthop, 1993,(296): 242-248.
  • 9Espehaug B, Engesaeter LB, Vollset SE, et al. Antibiotic prophylaxis in total hip arthroplasty. Review of 10 905 primary cemented total hip replacements reported to the Norwegian arthroplasty register,1987 to 1995. J Bone Joint Surg (Br), 1997, 79: 590-595.
  • 10Strachan CJ. Antibiotic prophylaxis in peripheral vascular and orthopaedic prosthetic surgery. J Antimicrob Chemother, 1993, 31Suppl B: 65-78.

共引文献38

同被引文献53

引证文献3

二级引证文献22

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部