摘要
目的:观察慢性乙型肝炎不同中医证侯机体免疫功能的动态变化,探讨慢性乙型肝炎中医证型与临床免疫指标的关联性。方法:选择初次治疗的慢性乙型肝炎肝胆湿热证和肝郁脾虚证患者各30例,动态观察两组患者血清CD_3^+、CD_4^+、CD_8^+水平及IgA、IgM、IgG含量的变化。结果:肝胆湿热型患者CD_3^+水平在初次、随访8周和16周时均明显升高,与肝郁脾虚型患者相应数值相比差异均有统计学意义(P<0.05)。两组患者初次、随访8周和16周时CD_4^+水平差异均有统计学意义(P<0.05),肝胆湿热组高于肝郁脾虚组。两组患者初次IgM含量差异有统计学意义,肝胆湿热组低于肝郁脾虚组(P<0.05),随访8周和16周时两组IgM含量差异均无统计学意义(P>0.05)。两组患者CD_8^+、IgA、IgG水平比较差异均无统计学意义(P>0.05);肝胆湿热组患者不同时间点血清CD_3^+、CD_4^+、CD_8^+水平及IgA、IgM、IgG含量差异无统计学意义(P>0.05),肝郁脾虚组患者不同时间点血清CD_3^+、CD_4^+、CD_8^+水平及IgA、IgM、IgG含量差异亦无统计学意义(P>0.05)。结论:①慢性乙型肝炎中医证型与机体免疫功能有一定的关联性,相关免疫指标可作为中医辨证分型的参考依据;②不同中医证型慢性乙型肝炎患者免疫功能具有一定稳定性。
Objective：To observe the dynamic changes of immune function in chronic hepatitis B with different TCM syndromes, and to explore the relevance between chronic hepatitis B （CHB） TCM types and clinical immune markers. Methods：The initial treatment patients who were corresponding to diagnosis on chronic hepatitis B standards were select- ed, with 30 cases in each of syndrome of dampness - heat of liver and gallbladder and syndrome of stagnation of liver qi and spleen deficiency. And the dynamic changes of two group serum CD3＋ , CD4＋ , CDs levels and IgA,IgM and IgG con- tents were observed. Results：At the first time,8 and 16 weeks of follow -up, CD3＋ levels were significantly increased in patients with syndrome of dampness - heat of liver and gallbladder, which were significantly different from that of patients with syndrome of stagnation of liver qi and spleen deficiency （P 〈 0.05 ）. At the first time, 8 and 16 weeks of follow - up, CD4＋ levels were statistically significant between two groups. The syndrome of dampness - heat of liver and gallbladder group was higher than that of syndrome of stagnation of liver qi and spleen deficiency group （ P 〈 0.05 ）. At the first time, IgM content was statistically significant between two groups. The syndrome of dampness - heat of liver and gallblad- der group was lower than that of syndrome of stagnation of liver qi and spleen deficiency group （P 〈 0. 05）. At 8 and 16 weeks of follow - up, there was no significant difference between two groups （ P 〉 0.05 ）. There were no significant differ- ences between the patients of two groups in serum CDs level and IgA and IgG contents （P 〉 0.05）. There were no sig- nificant differences between the different time points of patients with syndrome of dampness - heat of liver and gallbladder in serum CD3＋ , CD4＋ , CDs levels and IgA, IgM, IgG contents （P 〉 0.05）. There were no significant differences between the different time points of patients with syndrome of dampness - heat of liver and gallbladder in serum CD3＋ , CD4＋ , CDs levels and IgA, IgM an IgG contents too （P 〉 0. 05）. Conclusion ： ①There was certain relevance between chronic hepatitisB TCM syndromes and immune function. The associated immune indicators should be as reference of TCM syndrome types. ②The immune function in patients of different TCM syndromes of chronic hepatitis B has certain stability.
出处
《中华中医药学刊》
CAS
2013年第11期2391-2393,共3页
Chinese Archives of Traditional Chinese Medicine
基金
教育部重点实验室开放基金资助项目(GS090201)
关键词
慢性乙型肝炎
中医证型
免疫功能
动态变化
关联性
chronic hepatitis B
TCM syndromes
immune function
dynamic changes
relevance
