摘要
以没食子酸甲酯为原料,经过6步反应(总产率为24％),对 1,4-苯并二噁烷类新木脂素天然产物Eusiderin G进行了全合成。合成反应的关键步骤是在强酸性离子交换树脂催化下,分子内的醇羟基与酚羟基之间发生脱水反应,关环形成1,4-苯并二噁烷骨架化合物。该合成路线具有简便易行、产率较高、副反应少的特点,可适用于其它具有生理活性的1,4-苯二噁烷类化合物的合成。
An efficient transformation of methyl gallate to Eusiderin G7, a neolignan with 1,4- benzodioxane nuclei, in six steps with 24% overall yield is reported. This route is distinctly shorter, more economic and efficient than any of the previous approaches to the target reported in the literature. The key step is a cyclization of an dihydroxy intermediate 4 catalysted by a strong acid ion exchange resin to give 1,4- benzodioxane skeleton.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2000年第6期910-914,共5页
Chinese Journal of Organic Chemistry
