摘要
两亲性金属酞菁配合物二磺酸基二邻苯二甲酰亚胺甲基酞菁锌 (ZnPcS2 P2 )能有选择性地滞留在组织中 ,是一种新型的光动力治疗肿瘤的光敏剂。有关酞菁化合物治疗肿瘤的机制目前还不清楚 ,而对在CEL溶液中该光敏剂状态的研究对阐明其机制有重要意义。本文对在不同浓度CEL溶液中的二磺酸基二邻苯二甲酰亚胺甲基酞菁锌的吸收光谱和荧光光谱进行了研究 ,探讨了它在溶液中的聚集状态 ,通过分析确定其聚集态为二聚体 ,并获得其平衡常数和单体的摩尔吸光系数。
Sulfonated Phthalimidomethyl Zinc Phthalocyanine is a new photodynamic therapy reagent,it can be selectively attacked to cell,but how it attacks the target cell is still unknowable.The aggregation state of photosensitizer is significant to its mechanism proved in CEL solution.The aggregation of ZnPcS 2P 2 in CEL has been studied with absorption spectroscopy and fluorescence spectroscopy.The aggregation state is dimer through theory analysis,monomer molar absorption coefficient as well as equilibrium constant were estimated.
出处
《光谱学与光谱分析》
SCIE
EI
CAS
CSCD
北大核心
2000年第6期875-877,共3页
Spectroscopy and Spectral Analysis
基金
国家重点攻关项目
福建省科委资助项目
厦门大学固体表面物理化学重点实验室部分资助课题
