摘要
目的:研究高海拔地区急性重症脑功能损伤患者血清神经元特异性烯醇化酶(NSE)的动态变化及意义,评价NSE与急性重症脑功能损伤的程度及预后的关系。方法:应用放射免疫法对20例高海拔地区急性重症脑功能损伤组发病第1天、第2天、第3天的血清NSE的含量进行动态监测,同时测定20例正常对照组的相应水平。将发病第1天血浆NSE的含量与脑损伤的程度、临床预后进行相关性分析。结果:①急性重症脑功能损伤组发病第1天、第2天、第3天的血清NSE水平均高于正常对照组(P<0.05),第1天与第2天、第3天的血清NSE水平有明显差异(P<0.05),第2天、第3天的血清NSE水平无明显差异(P>0.05);②急性重症脑功能损伤组血清NSE含量的峰值出现在发病后第1天;③急性重症脑功能损伤组发病第1天血清NSE与脑损伤程度呈显著正相关(R=0.523,P<0.05),与临床预后呈显著负相关(R=-0.565,P<0.05)。结论:NSE是判断急性重症脑功能损伤程度、预测临床预后的一个重要指标。
Objective：To evaluate the dynamic changes of neuron - specific enolase （NSE） in serum level in patients with acute severe brain impairment to determine the correlation between brain impairment and clinic out- come. Methods：This study was consisted of the NSE group and the healthy controls group of 20 subjects each. Vain blood samples were collected on day 1, days 2 and 3 after incidence of NSE, and serum level of NSE was measured by radio - immunoassay in the both groups. Clinical correlation with level of NSE on the first day and brain damage as well prognosis was analyzed. Results： Serum level of NSE in test group on day 1,2 and 3 were significantly higher than that in control （ P 〈 0.05 ）, as compared with the first day when peak value of NSE happened, level of NSE was significantly higher on the 2nd day and third day （ P 〈 0.05 ）. No difference between the 2nd and third day （ P 〉 0.05）. If level of NSE on the first day in test group was higher, the severity of brain injury was greater, and there was a lower the GCS score and worse prognosis. Conclusions：The serum level of NSE is an important index for judge of severity and prognosis of acute severe brain impairment.
出处
《高原医学杂志》
CAS
2013年第1期1-4,共4页
Journal of High Altitude Medicine
