摘要
目的研究住院胆石症患者胆汁中肠杆菌科菌群的分布及菌种耐药性变迁,为临床合理用药提供参考。方法采用分离鉴定技术和药敏试验方法,对某医院住院胆石症患者胆汁中肠杆菌进行了分离培养和鉴定监测。结果从1 150份送检的胆石症病人胆汁标本中,共分离出肠道杆菌346株,总检出率为30.1%。检出的肠杆菌科细菌中,大肠埃希菌构成比为52.89%,肺炎克雷伯菌占17.63%,阴沟肠杆菌占10.12%,分居前三位。胆汁中分离的大肠埃希菌对广谱青霉素、头孢菌素类和喹诺酮类抗菌药物具有较高耐药率,肺炎克雷伯菌和阴沟肠杆菌对部分抗菌药物也显示了不同程度的耐药性。结论胆石症患者胆道感染以肠杆菌科为主要病原菌,且普遍耐药。
Objective To study the bile Enterobacteriaceae flora distribution and the transition of bacteria resistance of cholelithiasis patients so as to provide a reference for the clinical use of drugs. Methods Isolation and identification technology and drug sensitive test were used for the isolating and identification monitoring of the Enterobacteriaceae from the bile samples of the hospitalized patients in a hospital. Results A total of 346 isolates of Enteric bacilli were detected from 1150 copies of the cholelithiasis patients bile samples, with the total detection rate of 30. 1%. The top three detected bacte- ria of Enterobacteriaceae were Escherichia coli （ 52. 89% ） , Klebsiella pneumoniae （ 17.63% ） , Enterobacter cloacae （10. 12% ）. The drug sensitive results of Escherichia coli showed a high resistance rate to broad -spectrum Penicillin, Cephalosporins and Quinolones; KlebsieUa pneumoniae and Enterobacter cloacae showed different degrees of resistance to part antimicrohial drugs. Conclusion Enterobacteriaceae is the main bacteria for biliary tract infection of patients with cholelithiasis which is generally resistant to antimicrobials.
出处
《中国消毒学杂志》
CAS
北大核心
2013年第10期920-922,共3页
Chinese Journal of Disinfection
关键词
胆汁
肠杆菌科
医院感染
耐药性
bile
Enterobacteriaceae
hospital infection
drug resistance
