摘要
Induced pluripotent stem cells （iPSCs） are generated by ectopic expression of defined transcription factors in somatic cells. They can undergo unlimited self-renewal and maintain the embryonic stem cells （ESCs）-like ability to differentiate into all three germ layers, iPSCs can poten- tially provide unlimited autologous cells for therapy and therefore hold great promise for regener- ative medicine. Here we reviewed the recent advances in iPSC studies on disease modeling and clinical treatment as well as challenges correlated with clinical development of iPSCs, like tumori- genicity, immunogcnicity and genomic instability.
Induced pluripotent stem cells （iPSCs） are generated by ectopic expression of defined transcription factors in somatic cells. They can undergo unlimited self-renewal and maintain the embryonic stem cells （ESCs）-like ability to differentiate into all three germ layers, iPSCs can poten- tially provide unlimited autologous cells for therapy and therefore hold great promise for regener- ative medicine. Here we reviewed the recent advances in iPSC studies on disease modeling and clinical treatment as well as challenges correlated with clinical development of iPSCs, like tumori- genicity, immunogcnicity and genomic instability.
基金
supported by grants from the National Basic Research Program of China(Grant No.2012CB966901)
the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDA01040108)
the National Natural Science Foundation of China(Grant No.31271592) to TZ
