摘要
目的揭示和比较血清C-反应蛋白、白介素-1β、白介素．6、肿瘤坏死因子-α浓度对脑出血急性期早期神经功能恶化的预测价值。方法选取86例急性基底节区出血患者作为病例组和86例健康体检者作为对照组。记录脑出血患者入院时血肿量、脑室出血、NIHSS评分及早期神经功能恶化等临床资料。采用ELISA法测定血清C-反应蛋白、白介素-1β、白介素-6、肿瘤坏死因子-α浓度。统计分析这些炎性因子对早期神经功能恶化的预测价值。结果经独立样本t检验，病例组（或脑室出血患者或早期神经功能恶化患者）血清C-反应蛋白、白介素-1β、白介素-6、肿瘤坏死因子．仅浓度均较对照组（或非脑室出血患者或非早期神经功能恶化患者）明显增高（均P〈0．05）。行Pearson相关检验，人院时血肿量及NIHSS评分与血清C-反应蛋白、白介素-1β、白介素-6、肿瘤坏死因子．仪浓度均显著正相关性（均P〈0．05）。ROC曲线分析显示，血清C-反应蛋白、白介素-1β、白介素-6、肿瘤坏死因子．d浓度对急性期早期神经功能恶化均有显著预测价值，且它们的曲线下面积比较，差异均无统计学意义（均P〉0．05）。结论C-反应蛋白、白介素-113、白介素-6、肿瘤坏死因子．理可能参与脑出血急性期早期神经功能恶化的炎症反应过程，临床检测这些因子可更好预测早期神经功能恶化的发生。
Objective To investigate and compare predictive values of serum C-reactive protein （ CRP ） , interleukin- 1 β （ IL-1β ） , interleukin-6 （ IL-6 ） and tumor necrosis factor-α （ TNF-α） concentrations for early neurologic deterioration （ END ） after intracerebral hemorrhage. Methods 86 patients with acute basal ganglia hemorrhage were recruited as case group, and 86 healthy individuals from physical examinees were chosen as control group. Clinical materials of intracerebral hemorrhage patients including on admission hematoma volume, intraventrieular hemorrhage, and NIHSS score as well as END were recorded. Serum CRP, IL-1 β, IL-6 and TNF- α concentrations were measured by ELISA. Predictive values of these biomarkers for END were analyzed statistically. Results Using independent-samples t test, serum CRP, IL-1β, IL-6 and TNF- α concentrations were statistically significantly higher in treatment group than in control group, in patients with intraventricular hemorrhage than in those without intraventricular hemorrhage, and in patients with END than in those without END （ all P〈0.05 ） . Using Pearson test, on admission hematoma volume and NIHSS score were highly associated with serum CRP, IL-1 β, IL-6 and TNF- α concentrations （ all P〈0.05 ） . ROC analysis showed that serum CRP, IL-1 β, IL-6 and TNF- α concentrations statistically significantly predicted END, and when area under curves of these biomarkers was compared with each other, these differences were not statistically significant （ all P〉0.05 ） . Conclusions CRP, IL-1 β, IL-6 and TNF- α may be involved in inflammatory response of END in acute phase of intraeerebral hemorrhage, and clinical determination of these biomarkers in serum can markedly predict occurrence of END.
出处
《浙江临床医学》
2013年第11期1636-1638,共3页
Zhejiang Clinical Medical Journal
