摘要
目的观察神经节苷脂(GM-1)治疗早产儿缺氧缺血性脑病的临床疗效。方法将56例确诊为缺氧缺血性脑病而表现为脑室周围白质软化的早产儿随机分为两组,对照组28例给予保暖﹑吸氧﹑供能﹑防治感染﹑维持血糖正常﹑维持水电解质酸碱平衡、对症支持疗法;治疗组28例在上述常规治疗的基础上加用GM-1静脉注射,并定期观察和随访。结果治疗组有效率明显优于对照组,治疗组后遗症发生率显著低于对照组,差异有统计学意义(P<0.05)。结论神经节苷脂是治疗早产儿缺氧缺血后脑室周围白质软化的有效药物。
Objective To observe the clinical effect of ganglioside （GM-1） on preterm infants with hypoxic-ischemic encephalopathy.Methods A total of 56 cases diagnosed with hypoxic-isehemic encephalopathy manifested as periven- tricular leukomalacia in preterm infants were randomly divided into control group and treatment group.The control group of 28 patients were given the warm, oxygen ,energy supply ,the prevention and treatment of infections ,to main- tain normal blood glucose ,maintenance of water electrolyte acid-base balance, symptomatic and supportive therapy. Ganglioside was added to the treatment group plus the basis of conventional therapy.The therapeutic effects in the two groups were compared. Results The effective rate in treatment group was significantly higher than that in control group （P〈O.OS）.while the incidence of sequelae was distinctly lower.And the differences were statistically significant （P〈0.05）. Conclusion Ganglioside is an effective drug for the treatment of preterm infants with hypoxic-ischemie periventricular leukomalacia.
出处
《中国现代医生》
2013年第32期87-88,共2页
China Modern Doctor
关键词
早产儿
缺氧缺血性脑病
脑室周围白质软化
神经节苷脂
Preterm infants
Hypoxic-ischemic encephalopathy
Periventricular leukomalacia
Ganglioside
