摘要
目的探讨5%杀螺胺乙醇胺盐颗粒剂的制备方法及其杀螺效果。方法通过对润湿剂、分散剂、黏合剂和载体进行筛选,得出5%杀螺胺乙醇胺盐颗粒剂的最佳配方。将制得的氯硝柳胺乙醇胺盐颗粒剂进行堆密度、松密度、水分和热储稳定性评价,调查5%杀螺胺乙醇胺盐颗粒剂喷撒法的实验室和现场杀螺效果。结果5%杀螺胺乙醇胺盐颗粒剂的最佳配方和制备方法为:5%的杀螺胺乙醇胺盐、0.2%的十二烷基硫酸钠、1%的烷基酚聚氧乙烯基醚磺酸盐混合后,经气流粉碎机粉碎,得到粉末;再与93.7%的石英砂和0.1%的聚乙烯醇水溶液混合均匀,烘干,得杀螺胺乙醇胺盐颗粒剂。所制得的颗粒剂为干燥、自由流动的黄色颗粒,无可见外来物和硬块,粉尘少,适于机器施药;堆密度、松密度和水分分别为1.4、1.3g/ml和2.4%,热储稳定性合格。实验室采用0.5 g/m25%杀螺胺乙醇胺盐颗粒剂喷撒7 d后,或>1.0 g/m2剂量喷撒1 d后,钉螺死亡率均>95%;现场采用0.5 g/m25%杀螺胺乙醇胺盐颗粒剂喷撒7 d后,或>1.0 g/m2剂量喷撒1 d后,钉螺死亡率均>85%。结论5%杀螺胺乙醇胺盐颗粒剂杀螺效果较好,是一种适合现场应用的新型杀螺剂型。
Objective To explore the preparation of 5% niclosamide ethanolamine granules and evaluate its molluscicidal ef- fect. Methods The optimal formula was obtained by the selection of wetting agents, dispersants, adhesives and carriers. The mol- luscieidal effect of 5% nielosamide ethanolamine granules was measured by the spray methods in the laboratory and field. Re- suits The mixed 5% niclosamide ethanolamine, 0.2% sodium lauryl sulfate, and 1% alkylphenol sulfonie polyxyethylene ether sulfonate were crushed by gas flow, and then mixed with 93.7% quartz sand and 0.1% polyvinyl alcohol water solution, drying to 5% niclosamide ethanolamine granules. The density, bulk density, and moisture of 5% niclosamide ethanolamine granules were 1.4 g/ml, 1.3 g/ml, and 2.4%, respectively, and the hot storage stability was qualified. Under the lab condition, the death rates of Oncomelania hupensis snails sprayed with 0.5 g/m2 （7 d） or 1.0 g/m2 （1 d） of 5% niclosamide ethanolamine granules were higher than 95%. In the field, the death rates of the snails sprayed with 0.5 g/m2 （7 d） or 1.0 g/m2 （1 d） were higher than 85%. Conclu- sion There is a high molluseicidal effect of 5% niclosamide ethanolamine granules and it is suitable for field application.
出处
《中国血吸虫病防治杂志》
CAS
CSCD
2013年第5期473-476,共4页
Chinese Journal of Schistosomiasis Control
基金
江苏省医学领军人才项目(LJ201132)
江苏省血地寄防应用性科研课题(X201116)
关键词
杀螺胺乙醇胺盐
钉螺
颗粒剂
杀螺效果
Niclosamide ethanolamine
Oncomelania hupensis
Granule
Molluscicidal effect
