摘要
目的分析亚临床甲状腺功能减退症患者血脂、血糖、血尿酸水平的变化及临床意义。方法测定356例亚临床甲状腺功能减退症患者和331例健康对照组的体质量指数(BMI)、促甲状腺素(TSH)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、空腹血糖(FBG)、血尿酸(UA)水平,比较其结果的差异。结果亚临床甲状腺功能减退症组的BMI、TSH、TC、LDL-C、TG、FBG、UA水平高于对照组,FT4水平低于对照组,差异均有统计学意义(P<0.05);HDL-C虽有所下降但差异无统计学意义(P>0.05)。亚临床甲状腺功能减退症患者TSH水平与TC(r=0.254,P=0.000)、LDL-C(r=0.110,P=0.004)、TG(r=0.218,P=0.000)、BMI(r=0.119,P=0.002)和FBG(r=0.210,P=0.000)呈正相关;与HDL-C和UA无相关关系(P>0.05)。结论亚临床甲状腺功能减退症可能会影响血脂、FBG、UA的代谢。
Objective To investigate the changes of blood lipid, fasting blood glucose and blood uric acid and its clinical significance in people with subclinical hypothyroidism. Methods Body mass index (BMI), thyroid stimulating hormone (TSH), free triiodothyronine (FT3), free tetraiodothyronine (FT4), total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), fasting blood glucose (FBG) and uric acid (UA) were measured and compared in 356 people with subclinical hypothyroidism and 331 health people (controls). Results Compared to the control group, people with subclinical hypothyroidism had higher levels of BMI, TSH, TC, LDL-C, TG, FBG, UA (P^0. 05) and non-significant decrease of HDL-C (P〉0.05). The level of TSH was positively correlated with TC (r=0. 254), LDI.-C (r= 0.110), TG (r=0.218), BMI (r=0. 119) and FBG (r=0. 210) (P〈0. 05). The level of HDL-C was not correlated with TSH (P〉0.05). Conclusion Thyroid dysfunction may have an effect on the metabolism of blood lipid, FBG and UA.
出处
《四川大学学报(医学版)》
CAS
CSCD
北大核心
2013年第6期954-956,共3页
Journal of Sichuan University(Medical Sciences)
基金
国家自然科学基金(No.81100303)
四川省科技厅支撑项目(No.2011SZ0158)资助