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去整合素-蛋白酶23基因在恶性肿瘤中的研究进展 被引量：1

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摘要 去整合素-蛋白酶（ADAM）家族是归属于锌蛋白酶总属的一种跨膜蛋白。其主要功能表现为参与细胞膜的融合、细胞的迁移、决定细胞命运、参与细胞因子及生长因子的脱落等诸多方面，同时它还可以参与调节肌肉生长和受精等某些过程。
作者 王春敬 王夫景 胡天明 张好刚 李胜龙 张明坤
机构地区 哈尔滨医科大学附属第二医院普外三科
出处 《中国医师进修杂志》 2013年第30期76-78,共3页 Chinese Journal of Postgraduates of Medicine
基金 黑龙江省自然基金（D201002）
关键词 去整合素 蛋白酶 恶性肿瘤 基因 细胞膜 跨膜蛋白 生长因子 细胞因子
分类号 R730.2 [医药卫生—肿瘤]
  • 相关文献

参考文献27

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  • 2Choi JS, Kin KH, Jeon YK, et al. Promoter hypennethylation of the ADAM23 gene in coloreetal cancer cell lines and cancer tissues. Int J Cancer, 2009,124(6) : 1258-1262.
  • 3胡春燕,周建华,邓征浩,傅春燕,杨晓静,陈晨.ADAM23、αvβ3在非小细胞肺癌中的表达及临床意义[J].临床与实验病理学杂志,2010,26(4):433-437. 被引量：13
  • 4Takada H,Imoto I,Tsuda H,et al. ADAM23,a possible tumor suppressor gene,is frequently silenced in gastric cancers by homozygous deletion or aberrant promoter hypermethylation. Oncogene, 2005,24(54 ) : 8051-8060.
  • 5Costa FF, Verbisck NV, Salin AC, et al. Epigenetic silencing of the adhesion molecule ADAM23 is highly frequent in breast tumors.Oncogene, 2004,23 ( 7 ) : 1481 - 1488.
  • 6Calmon MF,Colonabo J,Carvalho F,et al. Methylation profile ot genes CDKN2A (p14 and pl6),DAPK1 ,CDHI ,and ADAM23 in head and neck cancer. Cancer Genet Cytogenet, 2007,173 ( 1 ) :31- 37.
  • 7Hagihara A, Miyamoto K, Furuta J,et al. Identification of 27 5'- CpG islands aberrantly methylated and 13 genes silenced in humar pancreatic cancers. Oncogene, 2004,23 ( 53 ) : 8705-8710.
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  • 10王夫景,于洪亮,张强,李胜龙.ADAM23基因在结直肠癌中的表达及其意义[J].世界华人消化杂志,2008,16(30):3406-3409. 被引量：6

二级参考文献73

  • 1崔明,徐海,杨彦.Pokemon蛋白在乳腺癌中的表达及意义[J].临床外科杂志,2007,15(6):399-401. 被引量：23
  • 2Costa FF, Verbisck NV, Salim AC, Ierardi DF, Pires LC, Sasahara RM, Sogayar MC, Zanata SM, Mackay A, O'Hare M, Soares F, Simpson AJ, Camargo AA. Epigenetic silencing of the adhesion molecule ADAM23 is highly frequent in breast tumors. Oncogene 2004; 23:1481-2488.
  • 3Seals DF, Courtneidge SA. The ADAMs family of metalloproteases: multidomain proteins with multiple functions. Genes Dev 2003; 17:7-30.
  • 4O'Shea C, McKie N, Buggy Y, Duggan C, Hill AD, McDermott E, O'Higgins N, Duffy MJ. Expression of ADAM-9 mRNA and protein in human breast cancer. Int J Cancer 2003; 105:754-761.
  • 5McCulloch DR, Akl P, Samaratunga H, Herington AC, Odorico DM. Expression of the disintegrin metalloprotease, ADAM-10, in prostate cancer and its regulation by dihydrotestosterone, insulin-like growth factor I, and epidermal growth factor in the prostate cancer cell model LNCaP. Clin Cancer Res 2004; 10:314-323.
  • 6Shintani Y, Higashiyama S, Ohta M, Hirabayashi H, Yamamoto S, Yoshimasu T, Matsuda H, Matsuura N. Overexpression of ADAM9 in non-small cell lung cancer correlates with brain metastasis. Cancer Res 2004; 64:4190-4196.
  • 7Kodama T, Ikeda E, Okada A, Ohtsuka T, Shimoda M, Shiomi T, Yoshida K, Nakada M, Ohuchi E, Okada Y. ADAM12 is selectively overexpressed in human glioblastomas and is associated with glioblastoma cell proliferation and shedding of heparin-binding epidermal growth factor. Am J Pathol 2004; 165:1743-1753.
  • 8Carl-McGrath S, Lendeckel U, Ebert M, Roessner A, Rocken C. The disintegrin-metalloproteinases ADAM9, ADAM12, and ADAM15 are upregulated in gastric cancer. Int J Onco12005; 26:17-24.
  • 9Hagihara A, Miyamoto K, Furuta J, Hiraoka N, Wakazono K, Seki S, Fukushima S, Tsao MS, Sugimura T, Ushijima T. Identification of 27 5' CpG islands aberrantly methylated and 13 genes silenced in human pancreatic cancers. Oncogene 2004; 23: 8705-8710.
  • 10Calmon MF, Colombo J, Carvalho F, Souza FP, Filho JF, Fukuyama EE, Camargo AA, Caballero OL, Tajara EH, Cordeiro JA, Rahal P. Methylation profile of genes CDKN2A (p14 and p16), DAPK1, CDH1, and ADAM23 in head and neck cancer. Cancer Genet Cytogenet 2007; 173:31-37.

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中国医师进修杂志
2013年 第30期

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