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预注阿托品对芬太尼诱发咳嗽的影响

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摘要 目的:观察全麻诱导前预注阿托品对芬太尼诱发咳嗽的影响。方法:100例拟行全麻择期手术患者随机均分为阿托品组(A组)和对照组(C组),两组分别于静脉注射芬太尼3μg/kg(3 s内注射完毕)前5min预注阿托品0.5 mg或生理盐水1 mL。记录预注阿托品或生理盐水前(T0)、预注后5 min(T1)、注射芬太尼后1 min(T2)、2 min(T3)的血流动力学改变和芬太尼注射后2 min内出现的咳嗽反应。结果:两组咳嗽发生率分别为30%和34%(A组为15例,C组为17例,P>0.05),两组间差异无统计学意义。A组在T1、T2、T3时HR明显加快,T1和T2时MBP明显升高(P<0.01)。C组在T2和T3时HR减慢(P<0.05)。结论:全麻诱导前预注阿托品0.5 mg并未能降低芬太尼诱发咳嗽的发生率。
出处 《实用医学杂志》 CAS 北大核心 2013年第21期3587-3588,共2页 The Journal of Practical Medicine
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