摘要
目的观察不同种α酮酸产品[科罗迪(KLD)和开同(KT)]对维持性血液透析患者营养状况的影响。方法选取48例在笔者所在科室行正规维持性血液透析患者,随机入组:KLD组加科罗迪0.12g/(kg·d),KT组加开同0.12g/(kg·d),对照组(CG组)未加用任何α酮酸。随访6个月,在0、3、6个月时分别检测患者相关营养指标:主观综合营养评估(SGA)、人体测量(BMI、TSF、MAC、MAMC、GST)、血清白蛋白(ALB)、C反应蛋白(CRP)、总胆固醇(TCH)、甘油三酯(TG)、血钙(Ca)、血磷(P)、甲状旁腺激素(PTH)、IgG、补体C3。结果随访前后比较,KLD及KT组SGA、人体测量、ALB、IgG、补体C3升高(P<0.05),CRP、P水平下降(P<0.05);和对照组比较,KLD组和KT组的SGA、人体测量、ALB、IgG、补体C3、P和CRP均有改善(P<0.05),但PTH、Kt/V(尿素清除指数)、总胆固醇、甘油三酯、血钙之间的差异无统计学意义(P>0.05)。随访过程中,KLD组、KT组和对照组均无明显不良反应。结论科罗迪和开同均能有效改善维持性血液透析患者的营养状况,且无明显不良反应。
Objective To observe the clinical effect of different kinds of a keto acid（KT and KLD） on nutritional status in mainte- nance hemodialysis patients. Methods Totally 48 maintenance hemodialysis patients were divided into three group randomly： KLD group with KLD 0.12 g/（ kg· d） , KT group with KT 0.12 g/（ kg ·d） and CG group（ conventional treatment group） with no a keto acid. SGA （subjective global assessment） , human body measurement （BMI, TSF, MAC, MAMC, GST） , serum albumin （ALB） , c -reactive pro- tein （CRP）, cholesterol （TCH）, triglyceride （TG）, blood calcium （Ca）, blood phosphorus （P）, parathyroid hormone （PTH）, IgG, C3concentration were detected respectively in the 0,3rd,6tb month. Data were analyzed among differnrt time and groups. Results In KLD and KT groups, SGA, human body measurement, ALB, IgG, C3 increased significantly（P 〈 0.05） and P, CRP level declined sig- nificantly（P 〈 0.05） after treatment. Compared with CG group, SGA, human body measurement, ALB, IgG, C3, P, CRP level abvious- ly improved in KL and KLD groups while PTH, Kt/V, TCH, TG, Ca had no statistical difference（ P 〉 0.05 ）. There was no adverse effect in all groups. Conclusion KLD and KT can effectively improve the nutrition status in maintenance hemodialysis patients with no obvious side effects.
出处
《医学研究杂志》
2013年第10期113-117,共5页
Journal of Medical Research
