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Suppressor of cytokine signaling 1 protects rat pancreatic islets from cytokine-induced apoptosis through Janus kinase/signal transducers and activators of transcription pathway 被引量：6

Suppressor of cytokine signaling 1 protects rat pancreatic islets from cytokine-induced apoptosis through Janus kinase/signal transducers and activators of transcription pathway
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摘要 Background Suppressor of cytokine signaling （SOCS） proteins are inhibitors of cytokine signaling pathway involved in negative feedback loops. Although SOCS1 is an important intracellular suppressor of apoptosis in a variety of cell types, its role in cytokine-induced pancreatic β-cell apoptosis remains unclear. The present study investigated potential effects of SOCS1 on the cytokine-induced pancreatic β-cell apoptosis. Background Suppressor of cytokine signaling （SOCS） proteins are inhibitors of cytokine signaling pathway involved in negative feedback loops. Although SOCS1 is an important intracellular suppressor of apoptosis in a variety of cell types, its role in cytokine-induced pancreatic β-cell apoptosis remains unclear. The present study investigated potential effects of SOCS1 on the cytokine-induced pancreatic β-cell apoptosis.
作者 Sun Qi Xiang Ruo-lan Yang Yan-li Feng Kai Zhang Kui Ding Wen-yi
机构地区 Chinese Acad Med Sci Chinese Acad Med Sci Peking Univ
出处 《Chinese Medical Journal》 SCIE CAS CSCD 2013年第21期4048-4053,共6页 中华医学杂志（英文版）
关键词 pancreatic fl-cell CYTOKINE apoptosis SOCS1 JAK/STAT pancreatic fl-cell cytokine apoptosis SOCS1 JAK/STAT
分类号 R363 [医药卫生—病理学]
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参考文献27

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Chinese Medical Journal
2013年 第21期

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