摘要
目的探讨10mg控释地诺前列酮用于足月妊娠期糖尿病(GDM)引产的有效性及安全性。方法将100例孕足月未破膜血糖控制良好的GDM单胎头位初产妇分为地诺前列酮组(50例)和缩宫素组(50例),比较两组患者的引产效果及并发症。结果地诺前列酮组用药后12h宫颈Bishop评分[(7.52±0.42)分]高于缩宫素组[(5.22±0.23)分],两组比较,差异有统计学意义(P<0.01);地诺前列酮组用药至临产时间[(8.77±1.86)h]、总产程[(10.24±1.37)h]均短于缩宫素组[(29.80±3.91)h,(15.30±1.15)h],两组比较,差异有统计学意义(P<0.01);地诺前列酮组剖宫产率(24.0%,12/50)与缩宫素组(78.0%,39/50)比较,差异有统计学意义(P<0.01);地诺前列酮组孕妇和新生儿血糖[(6.12±1.77)mmol/L,(3.02±0.42)mmol/L]与缩宫素组[(6.20±1.86)mmol/L,(3.15±0.63)mmol/L]比较,差异均无统计学意义(P>0.05);地诺前列酮组无新生儿窒息,缩宫素组发生1例新生儿窒息。结论 10mg控释地诺前列酮用于足月GDM患者引产安全有效,能显著提高患者的阴道分娩率,降低剖宫产率。
Objective To explore the effectiveness and safety of dinoprostone suppository used for induced labor of full- term pregnancy of cases with gestational diabetes mellitus （GDM） and without insulin treatment. Methods A total of 100 full - term pregnant women with GDM and the indications of induced labor and without in- sulin treatment were selected, including 50 cases in experimental group （ dinoprostone suppository group） and 50 cases in control group （ oxytocin group） ; the effects of induced labor and delivery conditions in the two groups were compared. Results The effect of cervical ripening in study group was superior to that in control group. The interval time from drug therapy to parturiency and the total stage of labor in experimental group were shorter than those in control group, the rate of cesarean section in experimental group was lower than that in control group, there was statistically significant difference （P〈0. 01） . There was no statistically significant difference in the incidences of post- partum hemorrhage and fetal distress, the changes of blood glucose during delivery period between the two groups. Conclu- sion Compared with oxytocin, dinoprostone suppository used for induced labor of full- term pregnancy of cases with GDM and without insulin treatment had the advantages of high successful rate and short stages of labor, which can improve the rate of vaginal delivery and reduce the rate of cesarean section.
出处
《中国妇产科临床杂志》
2013年第6期513-515,共3页
Chinese Journal of Clinical Obstetrics and Gynecology
关键词
地诺前列酮栓
妊娠期糖尿病
引产
足月妊娠
dinoproston＇e suppository
gestational diabetes mellitus
induced labor
full- term pregnancy
