摘要
目的探讨LED-蓝光对大鼠再生肝脏功能和形态学的影响。方法健康雄性SD大鼠24只随机分为3组,假手术组、模型组及LED干预组。采用Higgins改良方法制备大鼠肝叶结扎后肝再生的模型,在手术后的不同时间点,检测血清中谷丙转氨酶(ALT)和谷草转氨酶(AST)的含量变化和体质量变化。结果与假手术组相比,模型组和LED干预组在手术后1周血清中ALT和AST的水平均有升高(P<0.05),模型组ALT和AST水平在术后3周达到高峰,于4周恢复正常,LED干预组2周达高峰,3周恢复正常。术后4周时,LED组肝再生叶的比重高于假手术组和模型组(P<0.05)。结论 LED-蓝光对肝再生和功能恢复起明显的促进作用。
Objective To investigate the effects of blue light-emitting diodes（LED） on the liver regeneration in rats with hepatic lobes ligation. Methods 24 SD rats were randomly divided into three groups： Sham group, Model group and LED group. The model was established by ligating partial Liver.The rats of the LED group were shined by LED 30 minutes every day. The serum ALT and AST levels at different time points were measured. After 4 weeks, the weight of liver and rats were measured respectively. Results Compared with Sham group, the results of liver function： ALT, AST markedly increased in model rats（P〈0.05） in the first week. There was not any difference in ALT and AST between three groups. The ratio of the total weight of liver to body weight was higher than that of the model group lightened blue light than that in other groups（P〈0.05）. Conclusion Blue LED can promote liver regeneration and the recovery of the function of liver after ligating partial hepaticlobes.
出处
《医学研究与教育》
CAS
2013年第5期4-7,共4页
Medical Research and Education
基金
河北省科学技术研究与发展计划项目(112761160)
