摘要
目的探讨芪参颗粒联合运动疗法对心力衰竭大鼠心功能和左室重构的影响。方法采用冠脉左前降支(IAD)结扎法复制SD大鼠急性心肌梗死后心力衰竭模型,术后4周末,将动物随机分为模型组、芪参颗粒组、芪参颗粒联合运动疗法组及单纯运动疗法组,治疗后第8周末进行超声心动检测和心脏组织形态学观察。结果与假手术组相比,模型组大鼠左心室射血分数(IVEF)显著下降,左室舒张末期内径(IVEDd)及左室收缩末期内径(LVEDs)显著增加(P<0.01),染色示左心室短轴缩短率(LVFS)显著缩短(P<0.01);左室重量指数、心脏重量指数、室腔周长、室腔面积均显著增加(P<0.01);左心室重构病理特征显著。与模型组相比,芪参颗粒治疗组及芪参颗粒联合运动疗法组大鼠左室射血分数、左室短轴缩短率等指标均显著下降(P<0.05或P<0.01),室腔周长及面积显著缩小(P<0.01),且病理变化有所减轻。结论芪参颗粒联合运动疗法能够改善急性心肌梗死后心力衰竭大鼠心功能,延缓左室重构的发生和发展。
Objective To discuss the influences of Qishen Granules combining exercise therapy on cardiac function and left ventricular remodeling in rats with heart failure.Methods The model of heart failure induced by acute myocardial infarction was established by using thread approach of left anterior descending coronary artery （LAD） in Sprague-Dawley （SD） rats.Then the rats were randomly divided into model group,Qishen Granules treatment group （Qishen Granules group）,Qishen Granules combining exercise therapy group （combining group） and exercise therapy group （exercise group） 5 weeks after operation,which were given relevant treatment.At the end of 8th week after operation,cardiac functions were detected by using echocardiogram and cardiac histomorphological changes were observed in all groups.Results Left ventricular ejection fraction （LVEF） decreased significantly,left ventricular end-diastolic dimension （LVEDD） and LVEDs increased significantly （P ＜ 0.01）,LVFS shortened significantly （P ＜ 0.01）,left ventricular weight index,heart weight index,and left ventricular perimeter and area increased significantly （P ＜ 0.01） in model group compared with those in shamoperation group.The pathological characteristics of left ventricular remodeling in model group were remarkable.LVEF,LVEDs and other indexes decreased significantly （P ＜ 0.05,P ＜ 0.01）,left ventricular perimeter and area decreased significantly （P ＜0.01） in Qishen Granules group and combing group compared with those in model group.The pathological changes were alleviated in Qishen Granules group and combing group.Conclusion Qishen Granules combining exercise therapy can improve cardiac functions and postpone the formation and development of left ventricular remodeling in rats with heart failure induced by acute myocardial infarction.
出处
《北京中医药大学学报》
CAS
CSCD
北大核心
2013年第10期687-691,I0005,共6页
Journal of Beijing University of Traditional Chinese Medicine
基金
天津市教育科学"十二五"规划课题资助(No.HE4105)
关键词
心力衰竭
心功能
芪参颗粒
运动疗法
左心室重构
大鼠
heart failure
cardiac function
Qishen Granules
exercise therapy
left ventricular remodeling
rats
