摘要
目的 研究葡萄球菌对克林霉素诱导型耐药性,为临床合理用药提供依据.方法 对我院2010年1月～2012年12月分离的葡萄球菌进行克林霉素药敏测试（D试验）的数据进行回顾性分析.结果 分离得到115株葡萄球菌,97株表皮葡萄球菌、125株溶血葡萄球菌、14株其他葡萄球菌.葡萄球菌对于克林霉素的耐药情况分别为：金葡菌75.5％,表皮葡萄球菌65.2％,溶血葡萄球菌62.1％.15株对克林霉素耐药亚群的MIC为9～12 mg/L,其发生频率为10-4～10-3,其中11株金葡菌,4株溶血性葡萄球菌.将细菌进行传代培养后进行5种抗生素药敏显示,对克林霉素敏感5株,中介7株,耐药9株,敏感率23.8％利福平敏感2株,耐药4株,敏感率33.3％;左氧氟沙星敏感1株、耐药8株,敏感率11.1％,万古霉素敏感2株、中介7株,敏感率22.2％;四环素敏感3株,耐药6株,敏感率50％.结论 葡萄球菌对于克林霉素耐药率高,敏感率低,D试验阳性率高,对葡萄球菌耐药性应进行敏感性试验和D试验.
[ Objective ] To study the staphylococcus to clindamycin induction type resistance, provide a basis for clinical rational drug use. [Methods] The clinical data from January 2010 to December 2012 separate staphylococ- cus to clindamycin drug sensitive test （D test） data were retrospectively analyzed. [ Results ] 115 strains separated for staphylococcus aureus, 97 strains of staphylococcus epidermidis, 125 strains of staphylococci haemolyticus, 14 other strains of staphylococcus aureus. Staphylococcus for clindamycin resistance of respectively is： aureaus 75.5%, staphylococcus epidermidis 65.2%, staphylococci haemolyticus 62.1%. 15 strains to clindamyein resistance and the group of MIC for 9-12 rag/L, its occurrence frequency for 10-4-10-3, 11 of which strain aureus, 4 strains hemolytic staphylococcus. Will bacteria after subculture 5 kinds of antibiotics sensitive display, clindamycin sensitive 5 strains, intermediary 7 strains, resistance 9 strains, sensitive rate 23.8% rifampicin sensitive 2 strains, resistance 4 strains, sensitive rate 33.3%; Levofloxacin sensitive 1 strain resistance, eight strains, sensitive rate -11.1%, vancomycin sen- sitive 2 strains, intermediary 7 strains, sensitive rate 22.2%; Tetracycline sensitive 3 strains, resistant 6 strains, sen- sitive rate 50%. [ Conclusions ] Staphylococcus for clindamycin resistance, high sensitive rate is low, D-test positive rate is high, the detection staphylococcus for its resistance shall conduct sensitivity test and D test.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2013年第27期94-96,共3页
China Journal of Modern Medicine
关键词
葡萄球菌
克林霉素
诱导型
耐药
敏感
staphylococcus
clindamycin
induction
resistance
sensitive
