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诺和锐30联合格列美脲治疗需长期口服糖皮质激素的糖尿病临床疗效和安全性分析 被引量:2

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摘要 目的 探讨每日2次诺和锐30联合中餐前加服格列美脲治疗需长期维持口服糖皮质激素的糖尿病的血糖控制情况和低血糖的风险.方法 将30例需长期维持口服糖皮质激素的类固醇糖尿病和2型糖尿病的血糖控制不理想的患者,在保持原有控制饮食、适当运动前提下,应用诺和锐30早、晚餐前皮下注射,联合中餐前加服格列美脲1~3 mg,3个月后与加服格列美脲前诺和锐30联合中餐时嚼服阿卡波糖50 mg对照.结果 治疗后患者空腹及餐后2 h血糖、HbA1c与加服格列美脲前比较差异有统计学意义,且血糖波动减小、低血糖反应无明显增加.结论 诺和锐30联合格列美脲治疗需长期口服糖皮质激素的糖尿病可以减少中餐及晚餐前、后血糖波动,血糖控制达标,同时清晨及中餐前低血糖反应无增加,故在不愿意接受3次/d或4次/d注射胰岛素而要求2次/d注射胰岛素的需长期口服糖皮质激素的类固醇糖尿病和2型糖尿病患者中可考虑中餐时加用格列美脲.
作者 柳爱梅
机构地区 徐州民政医院
出处 《中国现代药物应用》 2013年第21期151-152,共2页 Chinese Journal of Modern Drug Application
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