摘要
HBV复制过程中存在逆转录,容易发生基因变异,表面抗原基因变异可能影响临床诊断、病毒复制以及疫苗效果等。从S基因变异的发生机制、生物学及临床意义等方面讨论研究现状和存在的问题。既往大多数研究仅仅限于S基因片段,将来须要更多地从HBV角度对S基因变异进行研究。
Hepatitis B virus （HBV） is prone to genetic variation because there is reverse transcription in the process of HBV replication. The gene mutation of hepatitis B surface antigen may affect clinical diagnosis of HBV infection, viral replication, and vaccine effect. The current research and existing problems are discussed from the following aspects ： the mechanism and biological and clinical significancr of S gene mutation. Most previous studies focused on S gene alone, so S gene should be considered as part of HBV DNA in the fimlre research on S gent mutation.
出处
《临床肝胆病杂志》
CAS
2013年第11期810-815,共6页
Journal of Clinical Hepatology
关键词
肝炎病毒
乙型
肝炎表面抗原
抗原变异
hepatitis B virus
hepatitis B surface antigens
antigenic variation
