摘要
本文应用酶谱法，观察了正常成年家兔及置固定式ＣｕＩＵＤ（ＦＣｕ－ＩＵＤ）或固定式含吲 哚美辛ＣｕＩＵＤ（ＦＩＣｕ－ＩＵＤ）的成年家兔宫腔冲洗液和子宫内膜组织中ＭＭＰｓ酶谱及其活 性变化。结果显示：ＦＣｕ－ＩＵＤ组与对照组比较，酶活性增强及酶种类明显增多。ＦＩＣｕ－ＩＵＤ 组与ＦＣｕ－ＩＵＤ组比较，部分ＭＭＰｓ酶活性明显降低，而且宫腔冲洗液和内膜组织活性降 低的酶种类有所不同。结果提示ＩＵＤ可以前列腺素为中介促进子宫局部 ＭＭＰｓ-生成，这 一作用可能与ＩＵＤ引起的异常出血有关。吲哚美辛减少ＩＵＤ引起异常出血的作用可能 与ＭＭＰｓ的生成减少有关。
In the current study,the activity of matrix metalloproteinases(MMPs) in the uterine flushing and endometrial tissue of normal adult rabbits wearing FCu-IUD or FICu-IUD (containing in- domethacin) was observed by zymograph on SDS-PAGE containing gelatin. These experiments showed that the activity and kind of MMPs in the FCu-IUD group were increased significantly as- compared with the control group. However, compared with the FCu-IUD group, the activities of some kinds of MMPs in the FICu-IUD group were decreased significantly and the kinds of activi- ty-decreased MMPs were different between the uterine flushing and endometrial tissue. These data suggest that IUD can enhance the activity of MMPs in rabbit uterus, intermediated by prostaglandins,and MMPs may have relation to IUD-induced menorrhagia and indomethecin re- duce IUD-induced menorrhagia by inhibiting part of MMPs synthesis.
出处
《生殖与避孕》
CAS
CSCD
北大核心
2000年第5期297-301,共5页
Reproduction and Contraception
