摘要
目的:研究舒胸胶囊微粉活血化瘀作用机理。方法:采用肾上腺素加冰浴的方法复制急性血瘀模型,观察舒胸胶囊微粉对大鼠血瘀模型全血黏度、血浆组织型纤溶酶原激活物(T-PA)及其抑制物(PAI)的变化,并与舒胸胶囊进行比较。结果:舒胸胶囊微粉能显著降低大鼠血瘀模型的全血黏度和血浆PAI含量,升高血浆T-PA含量;舒胸胶囊微粉低剂量组与舒胸胶囊高剂量组相比无显著性差异,高剂量组疗效明显优于舒胸胶囊高剂量组。结论:舒胸胶囊微粉具有明显的活血化瘀作用,其作用机制可能与改善血液流变性和纤溶系统活性有关。
Objective ： To investigate the effect mechanism of Shuxiong Capsule Micropowder on promoting blood circulation to resolve stasis. Methods ： Rat acute blood stasis models were replicated by means of epinephrine in ice - bath, change of whole blood viscosity, the tissue activator of plasminogen activator activity （ T - PA） , plasminogen activator [ inhibitor activity （ PAI ） were observed respectively, and contrasted with Shuxiong Capsule. Results ： Shuxiong Capsule Micropowder can significantly decrease whole blood viscosity and p｜asminogen activator I inhibitor activity ,and increase the tissue activator of plasminogen activator activity. There was no statistical difference between low dose group of Shuxiong Capsule Micropowder and high dose group of Shuxiong Capsule. The effect of high dose group of Shuxiong Capsule Micropowder is superior to high dose group of Shuxiong Capsule. Conclusion ： The results stated that Shuxiong Capsule Micropowder has remarkable function of activating blood circulation and eliminating stasis by improving hemorrheology and fibronolysis.
出处
《辽宁中医杂志》
CAS
2013年第11期2374-2376,共3页
Liaoning Journal of Traditional Chinese Medicine
基金
国家科技重大专项重大新药创制(2010ZX 09401-302-4-10)
关键词
舒胸胶囊微粉
急性血瘀模型
全血黏度
纤溶系统
大鼠
Shuxiong Capsule Micropowder
acute blood stasis model
whole blood viscosity
activity of fibrinolytic system
rat
