脑梗死患者颈动脉斑块稳定性与甲壳质酶蛋白40的分析被引量：1

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摘要目的探讨甲壳质酶蛋白40(YKL-40)及颈动脉粥样硬化与急性脑梗死的相关性。方法选取急性脑梗死患者87例作为病例组,对照组选取年龄、性别与病例组相匹配的无明显脑血管病表现者65例。通过颈部动脉彩色多普勒超声检查,了解颈部动脉管腔狭窄的程度及斑块稳定性,采用ELISA法检测血清YKL-40浓度。结果病例组斑块检出率和不稳定斑块比率显著高于对照组(P<0.05);病例组颈动脉狭窄率>50%者显著高于对照组(P<0.05);不稳定斑块组血清YKL-40浓度显著高于稳定斑块组(P<0.01)和无斑块组(P<0.01),稳定斑块组血清YKL-40浓度显著高于无斑块组(P<0.01)。结论颈动脉粥样硬化形成不稳定型斑块和颈动脉管腔狭窄率>50%是导致脑梗死的重要病因,血清YKL-40浓度可反映颈动脉粥样硬化斑块稳定性。

作者张堃胡为民

机构地区山西医科大学第二医院

出处《中西医结合心脑血管病杂志》 2013年第11期1291-1292,共2页 Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

关键词脑梗死颈动脉粥样硬化斑块甲壳质酶蛋白40

分类号 R743.3 [医药卫生—神经病学与精神病学]

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