摘要
目的：研究痴呆患者血浆同型半胱氨酸（Hey）浓度变化与痴呆患者认知功能障碍的关系。方法：筛选我科门诊及住院患者40例，进行MMSE量表评分，分为轻痴呆组、中痴呆组、重度痴呆组和对照组各10例，并监测患者血浆Hcy浓度进行对比分析。结果：各痴呆组血浆Hcy浓度较对照组明显增高；轻度痴呆组血浆同型半胱氨酸浓度较中度痴呆组和重度痴呆组降低，各痴呆组与对照组相比较，中重度痴呆组与轻度痴呆组相关性比较，均具有统计学意义（P〈0．05）；MMSE量表评分与Hcy水平呈负相关（r=-0．862，P〈0．05）。结论：痴呆患者血浆Hcy含量增高，并随痴呆程度的加重而增加。
To explore the relationship between plasma levels of homocysteine （Hcy） and dementia in elderly patients. METHODS： There were all 40 patients in our hospital, and 30 cases as study group and 10 as control group. According to mini -mental state examination score （MMSE） the patients with dementia were divided into three groups： mild dementia group, the dementia group and sever dementia group. The plasma of Hcy were compared and the relation between Hcy levels and degree of de- mentia was analyzed. RESULTS： Plasma levels of Hey in study group was significantly higher than those in control group （P 〈 0. 05 ）. Plasma levels of Hcy in mild dementia group were significantly lower than those in dementia and severe group （ P 〈 0.01 ）. Plasma levels of Hcy in dementia group were negatively related with MMSE score （ r = - 0. 862 ）. CONCLUSION ： Dementia is correlated to high Hey. The degree of dementia is significantly correlated to the rise of plasma levels of Hcy too.
出处
《国际老年医学杂志》
2013年第6期241-243,共3页
International Journal of Geriatrics
关键词
同型半胱氨酸
痴呆
认知障碍
Dementia
Homocysteine
Cognition disorders
