摘要
目的:评价国产奥沙利铂(Oxaliplatin,L-OHP)联合替加氟(Tegafur,FT-207)与奥沙利铂联合氟脲嘧啶(5-fluorouracil,5-FU)对结直肠癌术后辅助治疗的近期疗效及不良反应.方法:对2008-01/2010-12在湖南省肿瘤医院分别接受FT-207联合L-OHP方案及5-FU、L-OHP方案化疗的51例患者的临床资料进行回顾性分析.结果:FT-207联合L-OHP方案与5-FU联合L-O H P方案两组中位无病生存期分别为36mo、29 mo,两组比较差异有统计学意义.不良反应主要为轻中度的外周神经毒性、骨髓抑制和恶心呕吐.结论:替加氟可以替代氟尿嘧啶用于结直肠癌的术后辅助治疗.
AIM： To compare the therapeutic effects and safety of Tegafur or 5-fluorouracil （5-FU） com- bined with oxaliplatin in adjuvant therapy of colorectal cancer. METHODS： Clinical data for 51 patients who underwent adjuvant chemotherapy with Tega- fur or 5-FU combined with oxaliplatin from Jan- uary 2008 to December 2010 at Hunan Provincial Tumor Hospital were retrospectively analyzed. RESULTS： The median disease-free survival was significantly longer in the Tegafur plus ox-aliplatin group than in the 5-FU plus oxaliplatin group （36 mo vs 29 mo, P 〈 0.05）： Major toxic reactions were nausea, vomiting, myelosuppres- sion and peripheral neurotoxicity. CONCLUSION： Tegafur can replace fluorouracil for adjuvant therapy of colorectal cancer.
出处
《世界华人消化杂志》
CAS
北大核心
2013年第31期3460-3463,共4页
World Chinese Journal of Digestology
