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老年人子宫颈鳞癌中ACK1和基质金属蛋白酶-14表达的关系 被引量：5

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摘要 目的探讨老年人子宫颈鳞癌中ACK1和基质金属蛋白酶(MMP)-14的表达特征及关系。方法收集97例老年人子宫颈鳞癌标本作为观察组,65例老年人子宫肌瘤或子宫脱垂并行子宫全切术后慢性宫颈炎的上皮组织作为对照组,应用免疫组织化学技术检测两组中ACK1和MMP-14蛋白的表达。结果观察组中ACK1和MMP-14表达的阳性率明显高于对照组,观察组中ACK1和MMP-14表达的阳性率在不同病灶最大直径、不同淋巴结转移、是否累及阴道、是否伴脉管浸润分组的表达中差别有统计学意义(P<0.05)。观察组中ACK1和MMP-14的表达呈正相关性。结论老年人子宫颈鳞状细胞癌中ACK1和MMP-14具有协同作用和正向调节作用,ACK1可能通过降解细胞外基质发挥促肿瘤进展的作用。
作者 熊丽丽 田晓予
机构地区 河南科技大学第一附属医院妇产科
出处 《中国老年学杂志》 CAS CSCD 北大核心 2013年第22期5585-5587,共3页 Chinese Journal of Gerontology
关键词 子宫颈鳞癌 ACK1 基质金属蛋白酶(MMP)-14
分类号 R737 [医药卫生—肿瘤]
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参考文献13

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共引文献34

同被引文献56

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引证文献5

二级引证文献19

中国老年学杂志
2013年 第22期

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