摘要
糖尿病周围神经病变（DPN）患者中普遍存在维生素D缺乏的现象.1,25（OH）2D3作为维生素D的活性形式,通过与细胞内的维生素D受体（VDR）结合发挥生物学作用.已有研究证明DPN与维生素D缺乏之间具有相关性.维生素D缺乏导致DPN的机制尚不完全清楚,但有资料证实维生素D缺乏可导致神经系统发育障碍、神经损伤及神经变性性疾病,减弱抗炎作用,促进动脉粥样硬化发展,损害胰岛β细胞功能及上调基质金属蛋白酶水平,进一步导致DPN的发生和发展.
Vitamin D deficiency is commonly seen in patients with diabetic peripheral neuropathy （DPN）.Vitamin D,with 1,25 （OH） 2 D3 as its active form,takes effect by combination with vitamin D receptor （VDR）.It has been documented that DPN is relative with vitamin D deficiency.No specific studies were performed for the mechanism which vitamin D deficiency leads to DPN.While it has been proved that vitamin D deficiency plays a role in developmental disorder of nervous system,nerve injury,neurodegenerative diseases,attenuating anti-inflammatory effects,promoting atherosclerosis,damaging islet β cell function and upgrading matrix netalloproteinases,thereby leading to occurrence and development of DPN.
出处
《国际内分泌代谢杂志》
北大核心
2013年第6期412-414,418,共4页
International Journal of Endocrinology and Metabolism
关键词
糖尿病
维生素D
糖尿病周围神经病变
Diabetes mellitus
Vitamin D
Diabetic peripheral neuropathy
