摘要
目的:考察消癥止痛方凝胶膏剂大鼠的透皮行为。方法:以延胡索乙素为指标,采用改良Franz扩散池法进行实验,HPLC测定样品的含量。结果:24 h累积经皮渗透率和速率分别为20.20%,0.744 1μg·cm-2·h-1。结论:消癥止痛方凝胶膏剂大鼠的经皮渗透行为符合零级动力学模型且离散度较小,经皮渗透行为较为理想。
Objective： To study the transdermal behavior of Xiaozheng Zhitong cataplasm in rats. Method： With tetrahydrop- almatine as the index, the Franz diffusion cell method was adopted for the experiment. Sample content was determined with HPLC. Re- suit： The transdermal permeability and the transmission rate of tetrahydropalmatine accumulated for 24 h were 20. 20% and 0. 744 1 -2 h-1μg · cm-2 , respectively. Conclusion： The transdermal behaviors of Xiaozheng Zhitong cataplasm were ideal in conformity with the zero order kinetic model.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2013年第22期3907-3909,共3页
China Journal of Chinese Materia Medica
基金
国家自然科学基金项目(81273718)
关键词
消瘕止痛方
透皮吸收
延胡索乙素
HPLC
凝胶膏剂
Xiaozheng Zhitong cataplasm
transdermal absorption
tetrahydropalmatine
HPLC
cataplasm
