摘要
目的探讨白细胞介素-17(IL-17)在哮喘患者支气管肺泡灌洗液(BALF)中的变化及临床意义。方法 40例哮喘患者为哮喘组,依据病情严重程度分为中重度组(25例)和轻度组(15例);16例非哮喘患者为对照组。显微镜下计数BALF中炎性细胞占白细胞百分比,ELISA法检测BALF中IL-17,并测定1S用力呼气容积(FEV1)。结果中重度、轻度哮喘患者与对照组患者BALF中炎性细胞百分比、IL-17含量差异有统计学意义(P<0.05),中重度哮喘患者BALF中IL-17水平高于轻度哮喘患者,差异有统计学意义(P<0.05)。IL-17与炎性细胞百分比呈正相关(P<0.05)。结论 IL-17水平通过募集炎症细胞参与哮喘气道炎症的发生,IL-17可作为哮喘患者临床病情判定的参考指标。
Objective To investigate interleukin-17( IL-17) levels from the patients with bronchial asthma of different stages and the clinical implications. Methods Forty patients with bronchial asthma were divided into moderate or severe asthma( n = 25) and mild asthma groups( n = 15) and 16 patients without asthma were selected as the control group. Lung function was tested and cells in BALF were counted under the microscope. The levels of IL-17 in BALF were measured using ELISA. Results The percentages of neutrophils and eosinophils cells and IL-17in BALF were significantly higher in the two asthma groups than in the control group( P < 0. 05). The moderate or severe asthma group had significantly higher levels of IL-17 in BALF than the mild asthma group( P < 0. 05). BALF II-17 level was significantly positively correlated with the percentage of neutrophils,eosinophils in BALF. Conclusions IL-17 plays a role in asthmatic patient airway inflammation by mobilizing inflammation cells,and has a potential value in evaluating the severity of asthma.
出处
《齐齐哈尔医学院学报》
2013年第20期2990-2992,共3页
Journal of Qiqihar Medical University
基金
黑龙江省齐齐哈尔市科技厅攻关课题(SF2D-2012083)资助
