摘要
[目的]观察康莱特注射液（Kanglaite injection,KLT）联合体部伽玛刀对局部晚期胰腺癌的治疗效果。[方法]55例局部晚期胰腺癌患者随机分为两组,研究组28例：采用体部伽玛刀治疗,PTV覆盖95%以上临床靶体积（clinical target volume,CTV）,等剂量曲线为50%~60%。肿瘤单次周边剂量3.0~4.5Gy,治疗9~12次,同时给予康莱特注射液200ml/d,21d为1个疗程,共2个疗程。对照组：单纯行体部伽玛刀治疗。3个月后评价疗效,通过KPS评分、体重及疼痛变化,观察生存质量改善情况。[结果]两组完全缓解率分别为28.6%（8/28）和18.5%（5/27）;有效率分别为82.1%（23/28）和74.1%（20/27）。研究组Ⅲ级以上胃肠道反应发生率为3.5%（1/28）,对照组为29.6%（8/27）;研究组未发生Ⅲ级以上骨髓抑制（0/28）,对照组为18.5%（5/27）;研究组未发生Ⅲ级以上放射性肠炎（0/28）,对照组为14.8%（4/27）;研究组治疗前后KPS评分、体重增高及疼痛症状缓解明显高于对照组（P〈0.05）。[结论]体部伽玛刀治疗局部晚期胰腺癌安全有效,可提高局控率和有效率。康莱特配合体部伽玛刀治疗胰腺癌可以减轻治疗过程中胃肠道反应,减少Ⅲ级以上骨髓抑制和Ⅲ级以上放射性肠炎的发生,减轻疼痛症状,改善患者的生存质量。
[Purpose] To evaluate the clinical efficacy and toxicity of Kanglaite injection combined with γ-ray body stereotactic radiation in the treatment of locally advanced pancreatic cancer. [Methods] Fifty-five patients with locally advanced pancreatic cancer were randomized into two groups.The combination group received γ-ray stereotactic body radiation with isodose curve of 50%~60%,tumor encircling dose of 3.0~4.5 Gy per fraction for 9~12 fractions.Combined with Kanglaite injection 200ml/d for consecutive 21 days for two courses. Control group underwent γ-ray stereotactic body radiation alone.Toxicities and response were evaluated according to the criteria of WHO and RTOG. [Results]The CR in combination group and control group was 28.6%（8/28） and 18.5%（5/27）respectively（P 0.05）.Response rate of combination group was 82.1%（23/28）and 74.1%（20/27）in control group（P 0.05）.The rate of grade 3 ~4 gastrointestinal tract side reaction,grade 3 ~4 myelosuppression and grade 3 ~4 radiation enterocolitis in combination group and control group were 3.5%（1/28）,0%（0/28）,0%（0/28）and 29.6%（8/27）,18.5%（5/27）,14.8%（4/27）,respectively（P 0.05）.KPS and body weight score significantly increased and pain relieved in combination group after treatment（P0.05）.[Conclusion] Body gamma system treatment for pancreatic carcinoma can improve local control rate and effect for inoperable patients with local advanced pancreatic carcinoma. Kanglaite injection combined with γ-ray stereotactic body radiation Therapy can relieve severe toxicity in the treatment of locally advanced pancreatic cancer and improve quality of life.
出处
《中国肿瘤》
CAS
2013年第11期931-934,共4页
China Cancer
关键词
康莱特注射液
体部伽玛刀
胰腺癌
Kanglaite injection
γ-ray stereotactic body radiation therapy
pancreatic cancer
