摘要
目的 讨论服用氯氮平引致的癫痫发作与剂量之间的关系。方法 对 15 5 7名患者的住院资料进行了回顾性调查。结果 氯氮平引致癫痫发作的总发生率为 8.35‰ ,并与使用剂量呈正相关 (r =0 .81) ,剂量用至 45 0mg d以上时 ,发生率显著增高。结论 氯氮平引致癫痫发生率随剂量的增加而升高。作者认为 ,氯氮平治疗时用药量不宜太大。
Objective To explore the relationship between clozapine induced epilepsy and the dosage.Methods To have retrospective survey of 1557 cases of patients administered with clozapine.Results The incidence of epilepsy was 8.35‰.There was a positive correlation between epilepsy episode and clozapine dosage( r =0.81).When the dosage amounted to 450mg/d the incidence increased significantly.Conclusions Incidence of epileptic episode increased as the dosage increased.High dosage of clozapine was not recommended.
出处
《四川精神卫生》
2000年第4期231-232,共2页
Sichuan Mental Health
