摘要
[目的]观察祛湿化瘀方治疗非酒精性脂肪性肝病(NAFLD)的临床疗效。[方法]96例NAFLD患者随机分为祛湿化瘀方组(观察组,49例)和水飞蓟宾胶囊组(对照组,47例),疗程均为3个月。观察2组治疗前后肝功能[丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)]、血脂[总胆固醇(TC)、三酰甘油(TG)]、体质指数(BMI)和胰岛素抵抗指数(HOMA-IR)的变化,并比较2组疗效。[结果]观察组总有效率为85.71%,对照组为68.09%,观察组疗效优于对照组(P<0.05)。与治疗前比较,治疗后观察组AST[(43.39±5.49)U/L∶(86.52±10.44)U/L]、ALT[(48.61±7.23)U/L∶(95.03±12.27)U/L]、TC[(4.66±0.83)mmol/L∶(5.93±1.0)mmol/L]、TG[(1.57±0.44)mmol/L∶(3.79±0.62)mmol/L]、BMI[(24.61±3.17)∶(26.80±4.22)]、HOMA-IR[(1.74±0.24)∶(3.46±0.43)]均明显降低(P<0.05),而对照组仅AST[(58.35±6.16)U/L∶(85.71±9.93)U/L]、ALT[(61.18±8.54)U/L∶(95.14±12.40)U/L]有所降低。[结论]祛湿化瘀方具有改善血脂代谢、护肝降酶、减轻胰岛素抵抗的作用,是治疗NAFLD的有效方剂。
[Objective]To explore the effect and its mechanism of Qushihuayu decoction（QSHYD） on treatment of non-alcoholic fatty liver disease （NAFLD）.[Methods] Ninety-six cases of NAFLD patients were randomly divided into QSHYD treatment group （observtion group,n =49） and silibinin capsules treatment group （control group,n 47）,course of treatment was three months.The changes of liver function （AST,ALT）,cholesterol （TC,TG）,liver B-ultrasound,body mass index （BMI） and insulin resistance index （HOMA-IR） were observed before and after treatment,and the effects of the two groups were compared.[Results] In the observtion group the total effective rate was 85.71％,while 68.09％ in the control group （P＜0.05）.Compared with those of before treatment,the AST [（43.39 ± 5.49）U / L] vs [86.52 ± 10.44）U / L],ALT [（48.61 ± 7.23） U / L vs （95.03 ± 12.27）U / L],TC[（4.66 ± 0.83）mmol / L vs（5.93 ± 1.0）mmol / L],TG [（1.57 ± 0.44） mmol / L vs （3.79 ± 0.62）mmol / L],BMI [（24.61 ± 3.17）v （26.80 ± 4.22）]and HOMA-IR [（1.74 ± 0.24） vs （3.46 ± 0.43）] in observtion group significantly decreased after treatment （P＜0.05）,while in the control group,only AST [（58.35 ± 6.16）U / L vs （85.71 ± 9.93）U / L]and ALT[（61.18 ± 8.54）U / L vs （95.14 ± 12.40）U / L] decreased.[Conclusion] QSHYD could improve blood lipid metabolism,protect liver function,reduce transaminase and reduce insulin resistance,and it is an effective prescription of NAFLD.
出处
《中国中西医结合消化杂志》
CAS
2013年第11期584-586,共3页
Chinese Journal of Integrated Traditional and Western Medicine on Digestion
关键词
非酒精性脂肪肝病
祛湿化瘀方
肝功能
血脂
胰岛素抵抗
non-alcoholic fatty liver disease
Qushihuayu decoction
liver function
lipids
insulin resistance
