摘要
目的了解2012年河南省驻马店市艾滋病病毒（HIV）单阳家庭中，HIV阴性配偶的阳转情况及其影响因素。方法2012年7—12月，对河南省驻马店市单阳家庭进行横断面调查，收集HIV单阳家庭的基本信息、配偶间性行为信息、原阳者的治疗信息、CD4＋T淋巴细胞计数等，并对阴性配偶进行采血检测其HIV抗体阳转情况。结果共随访单阳家庭3850户，阴性配偶3850人，其中HIV抗体阳转17人，2012年驻马店市单阳家庭阴性配偶的HIV阳转率为0．44％。按原阳者性别分层，分别得到原阳者为男性的女性配偶阳转的危险因素为：近一年夫妻性生活不坚持使用安全套[比值比（OR）=31．176，95％可信区间（CI）：6．617-146．884，P〈0．0001]。原阳者为女性的男性配偶阳转的危险因素为：近一年夫妻性生活不坚持使用安全套（OR=37．859，95％CI：10．058～142．504，P〈0．0001），近一年夫妻性生活频次〉2次／月（OR=5．875，95％CI：1．200～28．771，P=0．0289），最近一次CD4＋T淋巴细胞计数≤350个／μL（OR=5．983，95％CI：1．213～29．503，P=0．0280）。综合来看，家庭内配偶间HIV传播的影响因素为：近一年夫妻性生活不坚持使用安全套（OR=32．557，95％CI：11．772-90．042，P〈0．0001），近一年夫妻性生活频次〉2次／月（OR=5．630，95％CI：1．775-17．854，P=0．0033），最近一次CD4＋T淋巴细胞计数≤350个／μL（OR=4．895，95％CI：1．536-15．606，P=0．0073）。结论驻马店市HIV单阳家庭阴性配偶阳转率较低，仍需要加强安全套的宣传以及CD4＋T淋巴细胞计数和病毒载量的检测工作。
Objective To study the seroconversion condition and seroconversion risk factors among human im- munodeficiency virus （HIV） serodiscordant couples in 2012 in Zhumadian city, Henan province. Methods A cross- sectional investigation of HIV serodiscordant couples was conducted between July and December in 2012 in Zhumadi- an. The basic information, medical, sexual behaviors and CD4＋ T counts of the sero-positive partners＇ were collect- ed, and blood specimens of the sero-negative partners were collected for testing HIV. Results A total of 3 850 HIV serodiscordant couples were followed up and 17 people showed HIV sero-positive conversion. The seroconversion rate was 0.44% in 2012. According to the gender stratification, the results were as followings： when the sero-posi- tire partners were male, the factor associated with increased risk of HIV seroconversion was that did not persist in using condoms （OR = 31. 176,95 % CI：6. 617% 146. 884, P〈0. 000 1）, when the sero-positive partners were female, the factors that associated with increased risk of HIV seroconversion were： had sexual behavior with frequency of2 times per month in the past year（OR = 5. 630,95% CI： 1.775- 17.854, P= 0.003 3）, did not persist in using condoms（OR = 37. 859, 95% CI：10. 058- 142. 504,P〈0. 000 1）, CD4＋T counts were 4350/μL in the last detec- tion（OR =5. 983,95%CI：1. 213- 29. 503,P=0. 028 0）. In general, factors that associated with increased risk of HIV were： had sexual behavior with frequency of 〉2 times per month in the past year （OR= 5. 630, 95% CI： 1. 775 17. 854,P=0. 003 3）, did not persist in using condoms（OR =32.557,95%CI： 11. 772- 90. 042,P〈0. 000 1）, CD4＋Tcounts was ≤350/μL in the last detection（OR =4. 895,95%CI：1. 536-15. 606,P=0. 007 3）. Conclusion HIV seroconversion rate was low in the HIV serodiscordant couples in Zhumadian. It was still necessary to strengthen the promotion of condoms use and the frequent detection of CD4＋ T counts and viral load.
出处
《中国艾滋病性病》
CAS
2013年第11期798-801,共4页
Chinese Journal of Aids & STD
基金
国家"十一五"重大传染病专项(2008ZX10001-003)
国家"十二五"重大传染病专项(2012ZX10001-001)~~
关键词
艾滋病病毒
单阳家庭
阳转
影响因素
HIV
Serodiscordant couples
Seroconversion
Influencing factors
