摘要
选近3年40例健康孕妇和35例子痫前期患者,其中轻度子痫前期20例,重度子痫前期15例。采用夹心酶联免疫法检测血浆甲壳质酶蛋白-40(YKL-40)和白细胞介素-18(IL-18)水平;透射比浊法检测血清C反应蛋白(CRP)水平。通过分析子痫前期患者及正常孕妇血浆YKL-40、IL-18及CRP水平,探讨子痫前期的发生及严重性与炎症关系。结果表明:血浆YKL-40、IL-18和CRP水平在子痫前期孕妇明显高于正常孕妇(P<0.05);血浆YKL-40和IL-18水平在重度子痫前期孕妇明显高于轻度子痫前期孕妇(P<0.05);在重度子痫前期孕妇CRP水平与轻度子痫前期孕妇相比无明显差异(P>0.05)。YKL-40、IL-18和CRP水平在子痫前期明显升高,YKL-40和IL-18水平与子痫前期疾病的严重性相关。
Forty healthy pregnant women and thirty-five patients with preeclampsia （including 20 milder preeclampsia and 15 severe preeclampsia） were included in this study. Serum levels of YKL-40 and IL-18 were measured using an enzyme-linked immunosorbent assay （ELLSA） and turbidimetry-immunoassay was used to detect the levels of C-reactive protein. The aim of this study was to evaluate the relationship of serum levels of YKL-40, IL-18 and CRP with inflammatory in preeclampsia. The results were as follows：Serum YKL-40, IL-18 levels and CRP levels were significantly higher in patients with preeclampsia than those in normal pregnant women （P〈0.05） ; Moreover, higher serum YKL-40, IL-18 levels were observed in patients with more severe condition than in patients with milder condition （P〈0.05）. There was, however, no significant difference in serum CRP levels between patients with more severe condition and those with milder condition （P〈0. 05）. Conclusion： YKL-40, IL-18 and CRP were elevated in patients with preeclampsia and levels of YKL-40, IL-18 were related to the severity of the disease.
出处
《扬州大学学报（农业与生命科学版）》
CAS
CSCD
北大核心
2013年第3期19-22,共4页
Journal of Yangzhou University：Agricultural and Life Science Edition
基金
国家自然科学基金资助项目(31371174)
江苏省自然科学基金资助项目(BK20131230)
