摘要
目的评价血小板平均体积(MPV)对急性冠状动脉综合征(ACS)的诊断价值。方法回顾性分析2007年8月至2011年1月151例胸痛患者[ACS患者69例(ACS组)、非ACS患者82例(非ACS组),以及54例健康对照个体(健康对照组)]的MPV检测结果,采用受试者工作曲线法分析MPV和心肌肌钙蛋白T(cTnT)对胸痛患者ACS的诊断价值。结果 ACS组MPV中位数(四分位间距)[11.00(9.40,12.90)fl]高于非ACS组[10.00(8.38,11.43)fl]和健康对照组[9.80(7.80,11.43)fl],差异均有统计学意义(P<0.01)。在胸痛患者中,MPV诊断ACS的曲线下面积(AUC)为0.65(95%CI:0.57～0.75),cTnT诊断ACS的AUC为0.99(95%CI:0.98～1.00),二者比较,差异有统计学意义(P<0.01)。当MPV的cut-off取值为12.600 fl时,其诊断特异性为0.98(0.91～1.00),敏感性为0.33(0.22～0.46);当cut-off取值为6.850 fl时,诊断特异性为0.04(0.01～0.10),敏感性为0.99(0.92～1.00)。结论 MPV可以作为诊断胸痛患者是否发生ACS的指标,且可弥补cTnT的不足。
Objective To evaluate the diagnostic value of mean platelet volume （MPV） in acute coronary syndrome （ACS）. Methods Retrospective analysis of MPV detection results was conducted on 151 patients with chest pain[69 cases with ACS （ACS group） and 82 cases without ACS （non-ACS group）] and 54 healthy people（healthy control group）. The ROC curve was used to analyze the diagnostic value of MPV and troponin T（cTnT） in diagnosis of ACS. Results The median（range interquartile） of MPV in ACS group [11.00 （9.40,12.90）fl] was higher than that in non-ACS group [10.00 （8.38,11.43 ）fl] and the healthy control group [9.80 （7.80,11.43）fl], and the difference had statistical significance （P〈0.01 ）. In the patients with chest pain, the area under the eurve（AUC） of MPV in diagnosis of ACS was 0.65 [95% confidence interval（C/） ：0.57-0.75],and the AUC of cTnT in diagno sis of ACS was 0.99 （95%CI：0.98-1.00）. The difference had statistical significance （P〈0.01 ）. When the cut-off point of MPV was defined as 12.600 fl, the specificity and sensitivity were 0.98 （0.91-1.00） and 0.33 （0.22-0.46） respectively. Meanwhile, the cut- off point of MPV was defined as 6.850 fl, the specificity and sensitivity were 0.04 （0.01-0.10） and 0.99 （0.92 - 1.00） respectively. Conclusion MPV can be taken as indicator to diagnose whether the patients with chest pain have developed to ACS, and it can make up for the limitation of cTnT.
出处
《现代医药卫生》
2013年第22期3368-3369,共2页
Journal of Modern Medicine & Health
