摘要
目的检测突发性聋患者血清热休克蛋白70(HSP70)含量,并初步探讨它与突发性聋患者临床特征之间的关系。方法本研究包括54例突发性聋患者(患者组)和54例正常人(对照组)。用高敏的酶联免疫吸附测定法检测血清HSP70,并观察血清HSP70与突发性聋患者临床特征的相关性,这些临床变量包括年龄,性别,病耳,发病时程,伴随症状(有无眩晕、耳鸣、脑梗死),发病初听力,治疗后听力,听力曲线类型,听力损失程度,听力恢复程度。结果突发性聋患者血清HSP70明显高于对照组,差异有统计学意义(P<0.05)。血清HSP70水平与突发性聋患者听力恢复程度有相关性(P<0.05)。结论血清HSP70可作为突发性聋患者发病初期的血浆标记物,推测HSP70可作为突发性聋患者的一个预后指标。
Objective To investigate the level of serum heat shock protein 70（HSP70） in patients with sudden sensorineural hearing loss（SSNHL） , and to observe the possible correlation between HSP70 and the clinical characters of SSNHL. Methods Fifty four patients with SSNHL and 54 normal controls were included in this study. Their serum HSP70 levels were detected with highly sensitive enzyme-linked immunoadsorbent assay test （ELISA）. Clinical variables including age, sex, ear, time course, accompanying symptoms （ such as vertigo, tinnitus, cerebral infarction） , initial andiometric results, final audiometric results,auditory rehabilitation degree, auditory severity degree and threshold curve type were analyzed to find the possible correlation between HSP70 and the clinical characters of SSNHL. Results Serum HSP70 levels were significantly higher in patients with SSNHL than the normal controls by ELISA test （ P 〈 0.05 ）. There was significant correlation between serum HSPT0 levels and the auditory rehabilitation degree in patients with SSNHL （P 〈0.05 ）. Conclusions This report shows elevated serum HSP70 levels in patients with SSNHL compared with normal controls. We suggest that the serum HSP70 might be used as the initial plasma marker of sudden deafness patients and that the serum HSP70 levels might have a clinical predicting role in patients with SSNHL.
出处
《中国眼耳鼻喉科杂志》
2013年第6期376-378,382,共4页
Chinese Journal of Ophthalmology and Otorhinolaryngology
关键词
突发性聋
热休克蛋白70
临床特征
Sudden sensorineural hearing loss
Heat shock protein 70
Clinical characteristic
