摘要
目的探讨超声造影对高强度聚焦超声(HIFU)治疗局限性前列腺癌早期疗效评价的应用价值。方法采用HIFU-2001型高强度聚焦超声肿瘤治疗系统,对17例局限性前列腺癌进行治疗。治疗前及治疗后1个月分别行超声造影检查,观察瘤体内部及周边组织血流灌注信号特点,据此判定疗效。同时根据直肠指检、经直肠前列腺B超检查前列腺肿块大小、血清PSA等结果进行客观疗效判定。将两疗效判定结果进行对比分析。结果 HIFU治疗前,所有前列腺低回声结节均呈快速高增强。HIFU治疗后,超声造影显示治疗有效15例,其中无增强12例、少量低增强3例;无效2例,仍表现为快速高增强。客观疗效判定有效15例,血清PSA下降幅度均≥50%,其中2例前列腺结节体积缩小≥50%;无效2例,血清PSA、前列腺低回声结节大小体积均与治疗前水平相当。客观疗效判定结果与超声造影结果相符。结论超声造影能准确显示HIFU治疗局限性前列腺癌的消融范围及程度,是评价早期治疗效果的可靠方法。
Objective To determine the value of contrast-enhanced ultrasound in evaluating the early efficacy of localized prostate cancer treated by high-intensity focused ultrasound （HIFU）. Methods 17 cases of localized prostate cancer were treated with HIFU-2001 system （Shanghai Jiao Tong University SUNTEC Corporation）. Contrast-enhanced ultrasound examination were performed before and one month after HIFU treatment. The efficacy was divided into active and inactive ac- cording to the perfusion signal change of the tumor nodules and surrounding tissues. On the other hand, efficacy was also evaluated by clinical examinations （digital rectal examination, transrectal ul- trasound and PSA level）. These two results were compared. Results Before HIFU treatment, the perfusion of all the tumor nodules were enhanced rapidly. One month after HIFU treatment, accord- ing to the contrast-enhanced image, 15 cases were diagnosed with active, among which 12 cases had no contrast agent signal in tumor nodules, 3 cases had a little contrast agent signal which was weaker than normal prostate tissue; 2 cases were diagnosed with inactive, whose tumors were still enhanced rapidly. According to the clinical examinations, 15 cases were diagnosed with active （15 cases PSA decrease≥50%, 2 cases tumor nodules volume decrease≥50%） ; 2 cases were diagnosed with inac- tive （no significant change of PSA level and nodules volume）. These two results were equal with each other. Conclusions Contrast-enhanced ultrasound can indicate the ablation area correctly, it can help to assess the therapeutic efficacy of HIFU treatment.
出处
《现代泌尿生殖肿瘤杂志》
2013年第5期287-290,共4页
Journal of Contemporary Urologic and Reproductive Oncology
基金
浙江省医药卫生科研基金资助项目(2006B115)
关键词
超声造影
高强度聚焦超声
局限性前列腺癌
Contrast-enhanced ultrasound
High-intensity focused ultrasound
Localizedprostate cancer
