摘要
药对整体功效所依赖的物质已不是2味药物的简单加和,而是这2味药不同成分相互作用形成的共同体。因此,药对功效物质研究是药对配伍研究的基础,对揭示药对的配伍效应、作用机制与中药新药创制等都具有重要意义。该文基于药对配伍体外煎煮过程发生的量变与质变、药对作用于机体或和机体相关环境后的变化等方面分析并总结了近年来药对功效物质基础研究的最新进展,以期进一步推动药对现代基础与应用的系统研究,揭示药对配伍的科学实质。
The total effect of Chinese medicine pair （CMP） was not the simply addition of two single herbs, but the interaction of their different components. Therefore, the research on the bio-active components of CMP is the basis of CMP compatibility study, and has important significance for revealing the compatibility effect and action mechanism, and creating traditional Chinese medicine （TCM） new drugs. This paper summed up the latest research progress of CMPon the basis of the bio-active components variation regularity of CMP from chemical solutions and content changes in vitro and the actions of CMP on bodies in vivo, in order to further drive the modern basic and applied research of CMP, and to reveal the scientific essence of CMP compatibility.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2013年第24期4196-4202,共7页
China Journal of Chinese Materia Medica
基金
国家科技支撑计划项目(2008BAI51B01)
国家自然科学基金项目(81274058)
江苏省高校自然科学重大基础研究项目(10KJA360039)
关键词
药对
配伍
功效物质
体外煎煮
体内变化
Chinese medicine pair
compatibility
bio-active component
in vitro decoction
variation in vivo
