摘要
目的:探讨注射用阿洛西林钠致不良反应(ADR)发生的特点及规律,为临床合理用药提供参考。方法:收集2007年1月-2012年12月某院注射用阿洛西林钠致ADR报告143例,就相关情况进行回顾性统计分析。结果:10岁以下儿童(65例次,45.45%)是ADR高发组;大多数ADR在首次用药的1 h内出现;ADR临床表现以皮肤及其附件损害最多(140例次,63.35%),其次是全身性损害(32例次,14.48%),主要表现为过敏反应;ADR中涉及联合用药的有35例,占24.48%。结论:临床应高度重视注射用阿洛西林钠致ADR的监测,确保安全、有效、合理用药。
OBJECTIVE： To explore the characteristics and general regularity of the adverse drug reactions （ADR） induced by Azlocillin sodium for injection, and to provide reference for rational medication in the clinic. METHODS： 143 ADR cases of Azlocillin sodium for injection collected from a hospital during Jan. 2007 to Dec. 2012 were analyzed retrospectively. RESULTS： Children under the age of 10 years was a high-risk cohort （65 cases, 45.45%）; most of ADRs appeared in 1 hour after fist medication. The clinical manifestations were lesions of skin and appendants （140 cases, accounting for 63.35% ）, followed by systemic prob- lems （32 cases, accounting for 14.48% ） as allergic reaction. There were 35 cases of drug combination, accounting for 24.48%. CONCLUSIONS： Great importance should be attached to the monitoring for ADRs induced by Azlocillin sodium for injection to guarantee the safety, effectiveness and rationality of drug use.
出处
《中国药房》
CAS
CSCD
2013年第48期4547-4549,共3页
China Pharmacy
