摘要
目的了解铜绿假单胞菌对各类抗菌药物的耐药性,以指导临床合理规范使用抗菌药物。方法收集2009年1月1日-2012年12月31日医院住院患者各种标本检出的铜绿假单胞菌,临床分离株药敏试验采用纸片扩散法(K-B法),结果采用WHONET 5.6进行统计分析。结果从临床标本中共分离出1553株铜绿假单胞菌,其中门诊患者分离147株占9.5%,住院患者1406株占90.5%;铜绿假单胞菌主要来源于呼吸内科、ICU、神经外科和烧伤科的患者,主要分离自痰标本;该菌对阿米卡星、头孢吡肟及头孢哌酮/舒巴坦的耐药率均<25.9%;除外2010年,2009-2012年铜绿假单胞菌对亚胺培南和美罗培南的耐药率呈下降趋势。结论铜绿假单胞菌对常用抗菌药物的耐药率仍处于较高水平,应加强铜绿假单胞菌的耐药性监测。
OBJECTIVE To investigate the drug resistance of Pseudomonas aeruginosa so as to provide guidance for the reasonable clinical use of antibiotics. METHODS The P. aeruginosa strains isolated from various specimens that were obtained from the hospitalized patients from Jan 1,2009 to Dec 31,2012 were collected, then the drug susceptibility testing of the clinical isolates was performed with the use of disc diffusion method （K-B method）, and the result was statistically analyzed by using the WHONET 5.6 software. RESULTS A total of 1553 isolates of P. aeruginosa have been isolated from the clinical specimens, among which there were 147 （9. 5%） isolates from the outpatients and 1406 （90.5%） isolates from the hospitalized patients. The P. aeruginosa strains were mainly isolated from the patients of the respiratory medicine department, ICU, neurosurgery department, and burn department, and the sputum specimens were the predominant specimen source. The drug resistance rates of the P. aeruginosa strains to amikacin, cefepime, and cefoperazone-sulbactam were less than 25.9%, and the drug resistance rates of the strains to imipenem and meropenem showed a downward trend from 2009 to 2012 except for 2010. CONCLUSION The drug resistance of the P. aeruginosa strains to the commonly used antibiotics remains at a high level, thus it is necessary to enhance the monitoring of the drug resistance of the P. aeruginosa.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2013年第24期6115-6117,共3页
Chinese Journal of Nosocomiology
基金
国家自然科学基金资助项目(81171618
81172737)
关键词
铜绿假单胞菌
药敏试验
抗菌药物
耐药性
Pseudomonas aeruginosa
Drug susceptibility testing
Antimicrobial agents Drug resistance
