摘要
丁丙诺啡(buprenorphine)是阿片μ受体部分激动剂,对κ,δ受体有弱的拮抗作用,具有高效镇痛而呼吸抑制、戒断症状、成瘾性等不良反应轻的特点。其皮肤渗透力强,血浆蛋白结合力高等药理学特性适于经皮给药。丁丙诺啡透皮贴剂具有丁丙诺啡的一般药理性能,且疗效稳定、作用持久,广泛应用于中重度疼痛治疗。美国FDA2010年7月1日批准其上市,本文就其药理作用、药动学、临床应用及不良反应进行综述。
Buprenorphine is partial agonist of Ix opioid receptor and weak antagonist of K and 8 receptors. It has highly analgesic efficacy and minor side effects, causing minimal respiratory depression, addiction and with drawal symptoms. It is suitable for transdermal delivery skin for its pharmacological properties such as strong skin penetration and high plasma protein binding force. Transdermal patch has general pharmacological properties of bu prenorphine and its effect is stable and permanent. Thus, It is widely used to relieve moderate or severe pain. On July 1, 2010, it was approved by FDA. In this paper, the pharmacology, pharmacokinetic, clinical application and adverse reaction of buprenorphine patches are reviewed.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2013年第23期2717-2720,共4页
Chinese Journal of New Drugs
关键词
丁丙诺啡
透皮贴剂
中重度疼痛
buprenorphine
transdermal patch
moderate or severe pain
