摘要
目的 探讨采用超普网塞UPP（Ultrapro Plug）经股部入路行股疝无张力修补术的临床疗效。方法 回顾分析2009年3月-2013年1月采用超普网塞UPP经股部入路行股疝无张力修补术的123例（126侧）股疝患者临床资料。男17例,女106例;年龄32～95岁,平均63.3岁。左侧48例,右侧72例;双侧3例。病程1个月～26年,中位时间25个月。可复性疝35例（36侧）,难复性疝88例（90侧）。根据美国麻醉医师协会（ASA）麻醉分级标准：Ⅰ级20例,Ⅱ级42例,Ⅲ级56例,Ⅳ级5例。记录手术时间、术后住院时间、手术并发症、复发和术后慢性疼痛发生情况。结果 患者手术时间7～28min,平均14.5min;术后住院时间2～96h,平均19.4h,其中112例〈24h。1例术后发生切口裂开,2例发生切口脂肪液化;无其他并发症发生。术后119例（122侧）患者获随访,随访时间4～50个月,中位时间18个月。随访期间股疝均无复发。其中2例（2侧）发生切口慢性疼痛,疼痛视觉模拟评分（VAS）标尺评价分别为20mm及30mm。结论 采用超普网塞UPP经股部入路行股疝修补术具有手术操作简便、手术时间短、并发症少以及复发率、术后慢性疼痛发生率低等优点。
Objective To investigate the expression and prognostic value of vascular endothelial growth factor receptor 3 （VEGFR-3） in human breast cancer. Methods A tissue microarray containing cores was constructed from 173 female patients with primary breast cancers （experimental group） and 19 female patients with benign breast lesions （control group） between March 2004 and June 2007. HE staining was performed to determine the quality of tissue microarray and immunohistochemistry staining was used to detect VEGFR-3 expression in the tissue microarray. Statistical analysis was performed to show the association between VEGFR-3 expression and clinicopathologic parameters. Results Histological examination showed that the tissue microarray had good quality, which could represent the histological characteristics of breast cancer and benign breast lesions. VEGFR-3 was expressed in 55.5% （96/173） breast cancer patients of experimental group, while the expression was negative in lesions of control group. VEGFR-3 expression rate had no significant relation with age, estrogen receptor, and progesterone receptor （P 〉 0.05）. VEGFR-3 expression rate correlated positively with tumor size and pathological staging compared to VEGFR-3 negative tumors （P 〈 0.05）. The positive expression rate of VEGFR-3 in breast cancer with lymph node metastasis was significantly higher than that without lymph node metastasis （P 〈 0.05）. Furthermore, VEGFR-3 positive staining correlated with human EGF receptor 2 expression （P 〈 0.05）. Conclusion The expressions of VEGFR-3 in human breast cancer have close relations with lymph node metastasis. Thus, VEGFR-3 may be a potential prognostic indicator and a new anti-cancer target for breast cancer.
出处
《中国修复重建外科杂志》
CAS
CSCD
北大核心
2013年第12期1487-1491,共5页
Chinese Journal of Reparative and Reconstructive Surgery
基金
基金项目：国家自然科学基金重点项目（81230009）
关键词
股疝
无张力修补术
股部入路
超普网塞UPP
Breast cancer Vascular endothelial growth factor receptor 3 Lymph node metastasis
