摘要
背景:鹿茸是惟一能够周期性再生的复杂哺乳动物器官,其再生过程是基于干细胞的存在。研究鹿茸再生机制,探索干细胞在哺乳动物器官再生中的作用对于再生生物学和再生医学研究具有重要的意义。目的:综述鹿茸再生研究,干细胞及相关因子在鹿茸再生中的作用。方法:应用计算机检索1994年1月至2012年10月PubMed数据库(http://www.ncbi.nlm.nih.gov/PubMed)。检索词为:deer antler;antler regeneration;stem cell,并限定文章语言种类为English。此外还手动查阅相关专著数部。纳入文章所述内容涉及鹿茸再生的组织学、形态学、鹿茸干细胞与微环境研究、相关细胞因子。排除重复研究和纳入标准无关的文章。结果与结论:共检索文献87篇,最终纳入文献36篇。决定鹿茸发生及再生的关键组织分别为生茸区骨膜和角柄骨膜,这两种组织中的细胞被定义为鹿茸干细胞。鹿茸干细胞上覆盖的皮肤组织构成了这些干细胞活动所需的特定微环境。多种细胞因子如胰岛素样生长因子、性激素、人表皮生长因子、血管内皮生长因子等参与了鹿茸再生及快速生长调控。探索鹿茸干细胞微环境内各组分间相互作用所需的信号因子、阐明其调控机制,对于揭示解鹿茸再生之谜,对了解干细胞在哺乳动物器官再生的作用具有十分重要的意义。
BACKGROUND： Deer antlers are the unique mammalian organs which can periodically regenerate, and the process is known as a stem cell-based event. Exploring the underlying mechanism of deer antler regeneration and indentifying the functional role of stem cell in mammalian organ regeneration are of great importance to regenerative biology and regenerative medicine. OBJECTIVE： To review the relevant literatures of the research progress in antler regeneration, as well as effects of stem cells and cytokines on antler regeneration. METHODS： A computer-based online search of PubMed （1994-01/2012-10） was performed for acquiring the articles in English by using the key words of deer antler; antler regeneration; stem cell. In addition, manual search was also performed for those literatures that cannot be readily obtained from internet search. Articles concerning antler regeneration histology, morphology, antler stem cells and micro-environmental studies, and related cytokines. Repetitive studies or articles that are unrelated to the criteria set for the article were excluded. RESULTS AND CONCLUSION： A total of 87 articles were obtained and finally 31 articles were selected. The key tissue types for antler regeneration are antlerogenic periosteum and pedicle periosteum, the cells within which are known as antler stem cells. The covering skin of antlerogenic periosteum and pedicle periosteum constitutes the functional niche for antler stem ceils. Numerous cytokines are involved in the process of antler fast growing and full regeneration, including insulin-like growth factor, sex hormones, human epidermal growth factor, and vascular endothelial growth factor. It is vitally important to identify the interacting molecules between the antler stem cells and their niche cell types, and to define the role of each molecule that plays in antler regeneration, which will greatly advance our knowledge of the stem cell-based mammalian organ regeneration.
出处
《中国组织工程研究》
CAS
CSCD
2013年第45期7961-7967,共7页
Chinese Journal of Tissue Engineering Research
基金
国家973前期研究专项(2011CB111500)
吉林省自然基金项目(20101575)
国家863项目(2011AA100603)~~
