摘要
目的:探讨肝硬化患者血凝四项指标和D-二聚体变化与临床的关系。方法:采用希森美康5100全自动血凝仪对216例肝硬化患者(Child–Pugh分级:A级62例,B级88例,C级66例)和84例健康体检者进行血凝四项和D-二聚体的检测。结果:与正常对照组相比,肝硬化各组PT、APTT、TT均明显延长(P<0.05),FIB明显降低(P<0.05),D-二聚体明显升高(P<0.05)。结论:血凝四项、D-二聚体的水平与肝硬化的严重程度密切相关,联合检测血凝四项、D-二聚体对肝硬化患者病情程度的评估、出血防治和预后判断具有重要的指导参考价值。
Objective：To investigate the clinical applications of four coagulation tests and D - dimer test in pa- tients with liver cirrhosis. Methods： Four coagulation tests and the D -dimer test were performed in 216 patients with liver cirrhosis （62 in Child - Pugh A group, 88 in B group and 66 in C group） and 84 healthy individuals by Sysmex Cs -5100 auto blood coagulation analyzer. Results：Compared with the control group, the prothrombin time （PT）, activated partial thromboplastin time （AFIT） and thrombin time （TT） in liver cirrhosis group were signifi- cantly prolonged （ P 〈 0.05 ）, the fibrinogen （FIB） was significantly lower （ P 〈 0.05 ）, and the D - dimer level was significantly higher （P 〈 0.05 ）. Conclusion： The four blood coagulation indexes and serum D -dimer level are correlated with disease status of liver cirrhosis. The combination detection of blood coagulation function and ser- um D - dimer may be significantly useful for the assessment of disease condition, the treatment and prevention hemorrhage in upper digestive tract and the prediction of prognosis for cirrhosis patients.
出处
《西北国防医学杂志》
CAS
2013年第6期519-520,共2页
Medical Journal of National Defending Forces in Northwest China
关键词
肝硬化
凝血四项
D-二聚体
Liver cirrhosis
Four coagulation tests
D -dimer
