摘要
背景:输卵管绝育器对女性生殖功能及内分泌平衡干扰少,方法简单有效。目的:阐述形状记忆输卵管避孕材料与其他输卵管避孕材料的优点及不良反应。方法:应用计算机检索1996至2013年万方医学网、中国知网、PubMed数据库有关形状记忆输卵管避孕材料与其他输卵管避孕材料的文章。结果与结论:目前应用的输卵管避孕材料主要有记忆金属生物材料、非降解高分子生物材料及可降解高分子生物材料。形状记忆输卵管避孕器植入后,对输卵管上皮具有短期炎性刺激作用,但其对上皮输卵管黏膜层的影响是暂时的,随着植入时间延长,输卵管上皮炎性反应逐渐减退,其管壁的绒毛逐渐修复,表明输卵管再通具有可复性的组织基础。聚乙烯材料具有高抗冲性、耐磨性、优良的对化学药品稳定性、吸水性、电绝缘性、生物惰性等,现在几乎是所有宫内节育器的支架材料。硅橡胶耐热、耐寒、无毒、耐生物老化,具有化学稳定性、生理惰性、物理机械性能,植入人体组织后不会引起异物反应。聚乳酸具有较好的化学惰性、易加工性和的生物相容性,植入体内5年后仍可能存在。
BACKGROUND： Intratubal contraceptive devices are simple and effective, which can cause less interference on female reproductive function and endocrine balance.OBJECTIVE： To explain the advantages and adverse effects of shape-memory intratubal contraceptive material and other intratubal contraceptive materials.METHODS： A computer-based search of Wanfang, CNKI and PubMed was performed to search related articles concerning shape-memory intratubal contraceptive material and other intratubal contraceptive materials published from 1996 to 2013.RESULTS AND CONCLUSION： The main intratubal contraceptive materials include memory metal biomaterials,non-degradable polymer biomaterials, and degradable polymer biomaterials. After implantation, the memoryshape intratubal contraceptive device plays a stimulating role in the tubal epithelium for a short time, but the effect on the mucosal epithelial layer of the fallopian tube is transient. With the increasing time of implantation,inflammatory reactions of the tubal epithelium relieve gradually with repair of villi on the tubal wall, indicating there is a reproductive tissue basis of fallopian tube recanalization. Polyethylene materials are characterized as high impact resistance, abrasion resistance, excellent stability to chemical drugs, water absorption, electric insulation,and bioinert, which are used as stent materials of almost all the intrauterine devices. Silicone is characterized as heat resistance, cold resistance, non-toxicity, resistance to biological aging, chemical stability, physical inertia,physical and mechanical properties, and silicone, after implantation into human body, cannot cause foreign body reaction.Polylactic acid has good chemical inertness, biocompatibility and ease of processing, and may be still present in the body after 5 years of implantation.
出处
《中国组织工程研究》
CAS
CSCD
2013年第47期8263-8268,共6页
Chinese Journal of Tissue Engineering Research
