摘要
目的分析上海市5家医院住院患者口服降糖药的使用情况和趋势,促进临床合理用药。方法回顾性分析上海市5家医院2007-2011年住院患者口服降糖药处方,对处方数、处方量和联合用药等进行统计,并计算用药频度(DDDs)、药物利用指数(DUI)和每日标准治疗费用(DDC)。结果使用频次较多的依次是阿卡波糖、二甲双胍、吡格列酮和瑞格列奈;药品费用较大的依次是阿卡波糖、瑞格列奈、吡格列酮和二甲双胍;大多数口服降糖药的DUI值在1左右;口服降糖药联合应用占总处方数的41.52%,最常见的二联用和三联用组合分别为α-葡萄糖苷酶抑制剂+双胍类和α-葡萄糖苷酶抑制剂+双胍类+磺酰脲类。结论阿卡波糖和二甲双胍是住院患者处方中使用最广泛的口服降糖药,吡格列酮和瑞格列奈的用量上升,磺酰脲类用量整体下降,但格列美脲的用量在增长。
AIM To evaluate the utilization of oral hypoglycemic agents among five hospitals inpatients in Shang- hai and facilitate rational use of drugs in clinical practice. METHODS The prescriptions of oral hypoglycemic agents in the five hospitals of Shanghai from 2007 to 2011 were retrospectively analyzed, in terms of the numbers of prescriptions, recipe quantity and drug combination. The DDDs, DUI and DDC were analyzed. RESULTS The most frequently used o- ral hypoglycemic agents were acarbose, metformin, pioglitazone and repaglinide. Oral hypoglycemic agents used with high cost were acarbose, repaglinide, pioglitazone and metformin. The DUI of most drugs was close to 1. The proportion of combined oral hypoglycemic agents accounted for 41.52% in all prescriptions. The two most commonly used combina- tions of two and three kinds of oral hypoglycemic agents were α-glycosidase inhibitor ＋ biguanide and α-glycosidase in- hibitor ＋ biguanide ＋ sulfonylurea. CONCLUSION Acarbose and metformin are the mostly used oral hypoglycemic a- gents. The consumption of pioglitazone and repaglinide is on the rise and the consumption of sulfonylurea is on the de- crease except for glimepiride.
出处
《中国临床药学杂志》
CAS
2013年第6期345-350,共6页
Chinese Journal of Clinical Pharmacy
关键词
口服降糖药
药物利用
合理用药
oral hypoglycemic agent
drug utilization
rational drug use
