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VEGF-C/VEGFR-3在恶性肿瘤淋巴转移中的作用及研究进展 被引量：8

Research progress of the effect of VEGFC/VEGFR-3 in malignant tumor lymph node metastases
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摘要 肿瘤分泌的VEGF-C与VEGFR-3结合后可诱导淋巴管内皮细胞增殖和迁移,刺激淋巴管的新生,介导肿瘤淋巴管的转移。通过竞争性抑制VEGFR-3的信号转导可有效阻止肿瘤淋巴管的转移,最终达到提高肿瘤治疗效果的作用。 Tumor secretion of combined VEGF -C and VEGFR -3 can be induced lymphatic endothelial cell prolif- eration and migration, stimulating lymphangial freshman, mediated tumor lymphatic transfer. Through the competitive inhibition VEGFR -3 signal transduction can effectively prevent tumor lymphatic transfer, and ultimately improve the effect of treatment of cancer.
作者 李晖 李亭葶 王熙才
机构地区 昆明医科大学第三附属医院肿瘤研究所
出处 《现代肿瘤医学》 CAS 2013年第12期2875-2877,共3页 Journal of Modern Oncology
基金 国家自然科学基金资助项目(编号:81060177) 云南省卫生厅专项基金资助项目(编号:2012WS0041)
关键词 VEGF—C VEGFR-3 恶性肿瘤 淋巴转移 VEGF - C/VEGFR - 3 malignant tumor lymph node metastases
分类号 R73-37 [医药卫生—肿瘤]
  • 相关文献

参考文献19

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二级参考文献49

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共引文献25

同被引文献87

  • 1陈敏,唐建武.VEGF-C在非小细胞肺癌中的表达及意义[J].肿瘤,2005,25(1):80-82. 被引量：8
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  • 3李炜,孟艳冬,赵玲,丁诗语,孙莉.灯盏细辛注射液对MCF-7细胞凋亡及血管生成作用的实验研究[J].甘肃中医,2006,19(9):47-49. 被引量：4
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引证文献8

二级引证文献47

现代肿瘤医学
2013年 第12期

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