摘要
目的 :探讨急性髓系白血病 (AML)的原发性耐药蛋白 p170、GSTP- 1等的表达和疗效、预后的关系。方法 :采集 AML 患者治疗前骨髓液 ,采用 ABC- AP法检测 p170、GSTP- 1和其他单抗。结果 :110 5例初治 AML中 12例 (11.4% )出现 p170或 GSTP- 1的阳性表达。 2耐药表达阳性的 12例中 CR6例 (5 0 % ) ,有效率为6 6 .7% ;12例中目前 7例死亡 ,2例复发 ,总生存曲线下降较快。无病生存曲线反映 18个月追踪仅剩 2 5 %左右。结论 :成人 AML原发性耐药的表达是治疗效果差的标志之一 ,与预后直接相关。
Objective:To analyse the relationship among the expression of multidrug resistance protein p170, GSTP-1 and the effectiveness of treatment and prognosis.Method:The bone marrow smears from newly diagnosed acute myeloid leukemia were studied by modified ABC-AP enzyme immunoassay method to evaluate the p170, GSTP-1 and the others. Result:①Twelve patients of 105( 11.4 %) had positive-expression of p170 or GSTP-1.②The CR rate was 50.0 %, the effective rate (CR+PR) was 66.7 % in positive-expression patients; The CR rate was 66.7 %,the effective rate(CR+PR) was 82.8 % in negative-expression patients.At present, seven patients died and two patients was relapsed from 12 positive-expression patients.The curve of Kaplan-Meier survival declined faster.Conclusion:Expression of MDR in adult patients with newly diagnosed acute myeloid leukemia was one of worse factors for effectiveness of treatment, and directly related to prognosis.
出处
《临床血液学杂志》
CAS
2000年第6期252-254,共3页
Journal of Clinical Hematology
