摘要
目的:观察芪丹饮配合中药灌肠治疗糖尿病肾病Ⅲ-Ⅳ期脾肾阳虚型的临床疗效。方法:将72例糖尿病肾病Ⅲ-Ⅳ期脾肾阳虚型患者随机分成治疗组和对照组各36例。两组均常规给予胰岛素控制血糖,治疗组在常规用药基础上口服芪丹饮并配合糖肾灌肠方保留灌肠治疗,对照组在常规用药基础上口服福辛普利片治疗,两组疗程均为10周。观察两组治疗前后空腹血糖、糖化血红蛋白、血脂、尿微量白蛋白排泄率及肾功能指标的变化。结果:两组治疗后空腹血糖、糖化血红蛋白、血脂较治疗前均明显下降(P<0.05),但组间比较仅血脂差异有统计学意义(P<0.05),提示治疗组对血脂的改善优于对照组;两组治疗后肾功能指标较治疗前均明显改善(P<0.05),治疗组改善更显著(P<0.05)。结论:芪丹饮配合中药灌肠可显著减少糖尿病肾病患者尿白蛋白排泄,改善肾功能,延缓糖尿病肾病进展。
Objective：To observe the clinical efficacy of Qidan decoction combined with traditional Chinese medicine （TCM） enema in stage III - IV diabetic nephropathy patients with syndrome of yang deficiency of spleen and kidney. Methods ： Seventy - two stage III - IV diabetic nephropathy patients with syndrome of yang deficiency of spleen and kidney were randomly divided into treatment group （ n = 36 ） and control group （ n = 36 ）. Both groups were given insulin to control blood glucose;in addition, the treatment group was orally given Qidan decoction and re- ceived TCM enema using the enema prescription for diabetic nephropathy, while the control group was orally given fosinopril tablets. The course of treatment was 10 weeks in both groups. After treatment, the changes in fasting blood glucose, glycosylated hemoglobin, blood lipids, urinary albumin excretion rate, and renal function indices were evalu- ated. Results：After treatment, both groups showed significant decreases in fasting blood glucose, glycosylated hemo- globin, and blood lipids （ P 〈 0.05 ）, but there was significant difference only in blood lipids between the two groups （P 〈 0. 05 ）, suggesting that the treatment group had a better improvement in blood lipids than the control group. In addition, both groups showed significant improvements in renal function indices after treatment （ P 〈 0.05 ）, and the treatment group had significantly more improvements （ P 〈 0. 05 ）. Conclusion ： Qidan decoction combined with TCM enema can significantly reduce urinary albumin excretion and improve renal function in patients with diabetic ne- phropathy, thus delaying the progression of this disease.
出处
《湖南中医杂志》
2013年第11期13-15,共3页
Hunan Journal of Traditional Chinese Medicine
基金
广东省中医药局建设中医药强省科研课题(编号:20111027)
关键词
糖尿病肾病
中医药疗法
芪丹饮
糖肾灌肠方
diabetic nephropathy
traditional Chinese medicine treatment
Qidan decoction
enema prescriptionfor diabetic nephropathy
